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Table 1 Volumetric variables in sheep breathing spontaneously, or subjected to mechanical ventilation, or pneumonectomy

From: Measuring extravascular lung water: animals and humans are not the same

Parameter

SB (n = 48)

MV (n = 51)

PE (n = 42)

ITBVI (ml/m2)

856 ± 106

804 ± 129

635 ± 116b,c

GEDVI (ml/m2)

654 ± 92

551 ± 91b

461 ± 97b,c

PBVI (ml/m2)

202 ± 32

253 ± 56b

176 ± 41b,c

ITBV:GEDV ratio

1.313 ± 0.063

1.463 ± 0.089b

1.389 ± 0.101b,c

Correlation between ITBVI and GEDVa

0.96

0.93

0.95

Regression equation

ITBVI = 1.16 × GEDVI + 92.45

ITBVI = 1.43 × GEDVI + 13.48

ITBVI = 1.21 × GEDVI + 73.72

  1. SB, spontaneous breathing; MV, mechanical ventilation with tidal volumes of 6 to 8 ml/kg and positive end-expiratory pressure 2 cmH2O; PE, pneumonectomy; ITBVI, intrathoracic blood volume index; GEDVI, global end-diastolic volume index; PBVI, pulmonary blood volume index; ITBV, intrathoracic blood volume; GEDV, global end-diastolic volume. All data are distributed normally and are presented as means ± SD. aPearson coefficient, r (p < 0.0001). bp < 0.05 compared with SB; cp < 0.05 compared with MV (analysis of variance followed by Scheffe's test).
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Critical Care

ISSN: 1364-8535