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Table 3 Estimates of population average clearance and terminal half-life at various post-dose red blood cell requirements

From: Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding

Population

RBC requirements (Units)

Estimated clearance (ml.kg-1.h-1)

Terminal half-life (h)

Hemophiliaa

NA

29

4.4

Trauma

0

36

2.6

 

8.7b

40

2.4

 

20

47

2.1

 

30

54

1.9

 

40

62

1.7

  1. aObtained in patients with hemophilia (see Materials and methods). bThis value corresponds to the trauma population average. NA, not applicable; RBC, red blood cell.
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Critical Care

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