Table 2 Population pharmacokinetic model parameter estimates (n = 230)
From: Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding
Variable | Estimate (95% CI) | Between patient CV |
|---|---|---|
Clearance (ml.kg-1.h-1) | 40 (37–44) | 30% |
Central compartment volume (ml.kg-1) | 89 (60–132) | 32% |
Inter-compartmental clearance (ml.kg-1.h-1) | 24 (8–76) | NA |
Peripheral compartment volume (ml.kg-1) | 31 (13–74) | NA |
Baseline concentration (U.ml-1) | 0.29 (0.27–0.31) | 39% |
ΔClearance/RBC | 1.014 (1.003–1.0025) | NA |
Initial half-life (h) | 0.6 (0.2–1.3) | NA |
Terminal half-life (h) | 2.4 (1.8–5.5) | NA |