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Table 1 Pharmacokinetic parameters of factor VII coagulant activity assessed by non-compartmental analysis in blunt and penetrating trauma patients with frequent sampling

From: Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding

 

Blunt (n = 6)

Penetrating (n = 15)

Cmax (U.ml-1)

81 (47–241) [76%]

58 (41–102) [27%]

Tmax (h)

0.9 (0.5–4.0) [110%]

1.2 (0.5–4.0) [86%]

AUC0–12h (U.h.ml-1)

305 (216–362) [17%]

311 [182–520] [26%]

Clearance (ml.kg-1.h-1)

41 (34–58) [21%]

40 (25–79) [30%]

Volume of distribution (ml.kg-1)

83 (28–143) [45%]

112 (66–165) [24%]

  1. Data are geometric means (min-max) and coefficient of variation [%]. There is no significant difference between the two groups. AUC0–12h, area under the plasma concentration-time profile from time of first dose (time zero) to 12 hours after first dose; Cmax, maximum plasma concentration; Tmax, time to maximum plasma concentration.
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Critical Care

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