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Table 4 Multiple regression analysis of factors predicting hospital death and discharge to a care facility

From: Corticosteroids influence the mortality and morbidity of acute critical illness

 

Wald chi-square

Odds ratio (95% confidence interval)

P

Hospital death a

   

Preadmission comorbidities

   

   Age per decade

22

3.2 (1.9–5.6)

<0.0001

   Female

6

1.3 (1.0–1.5)

0.0176

   Malignancy

18

1.7 (1.3–2.2)

<0.0001

Hospital and intensive care

   

   Medical admission

112

3.2 (2.6–3.9)

<0.0001

   Mechanical ventilation

74

2.6 (2.1–3.2)

<0.0001

   Maximal daily Sequential Organ Failure Assessment score >8

136

3.8 (3.0–4.8)

<0.0001

   Corticosteroid exposure (hydrocortisone, dexamethasone, methyl prednisone or prednisone)

11

1.4 (1.1–1.7)

0.001

Hospital diagnosis category

   

   Acute renal failure

81

3.0 (2.4–3.9)

<0.0001

   Cardiovascular

62

2.2 (1.8–2.7)

<0.0001

   Neurological

69

2.6 (2.1–3.3)

<0.0001

   Respiratory

16

1.5 (1.2–1.8)

<0.0001

Discharge to care facility b

   

Preadmission comorbidities

   

   Age per decade

137

7.9 (5.6–11.1)

<0.0001

   Female

19

1.3 (1.1–1.4)

<0.0001

   Cerebral vascular disease

24

1.6 (1.3–2.0)

<0.0001

   Degenerative brain disease

212

2.7 (2.3–3.0)

<0.0001

   Congestive heart failure

13

1.3 (1.1–1.5)

0.00040

   Chronic obstructive pulmonary disease

4

1.1 (0.9–1.3)

0.05880

   Cachexia

11

1.6 (1.2–2.1)

0.00040

   Diabetes mellitus

6

1.2 (1.0–1.4)

0.01

Hospital and intensive care

   

   Medical admission

118

1.9 (1.7–2.1)

<0.0001

   Corticosteroid exposure

   

Total hydrocortisone equivalent >900 mg

6

1.2 (1.0–1.4)

0.01

Maximal daily Sequential Organ Failure Assessment score ≥ 4

21

1.3 (1.2–1.5)

<0.0001

   Hospital-acquired infection

124

2.2 (1.9–2.6)

<0.0001

   Antifungal antibiotics

10

1.3 (1.1–1.6)

0.00160

   Tracheostomy

63

2.9 (2.3–3.8)

<0.0001

Hospital diagnosis category

   

   Neurological

57

1.7 (1.5–2.0)

<0.0001

   Respiratory

10

1.2 (1.1–1.4)

0.00200

   Postoperative complications

28

1.5 (1.3–1.7)

<0.0001

   Fluid and electrolyte abnormalities

13

1.2 (1.1–1.4)

0.00030

  1. aThe calibration of the multiple logistic model (lack of fit P = 0.9) and discrimination characteristic (area under the receiver operating characteristic curve = 0.88); P < 0.01 for all predictive factors. bThe calibration of the multiple logistic model (lack of fit P = 0.9) and discrimination characteristic (area under the receiver operating characteristic curve = 0.76); P < 0.01 for all predictive factors.
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Critical Care

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