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Table 1 Ventilatory parameters, hemodynamics, and blood gas analysis before and after induction of lung injury

From: Effect of a lung recruitment maneuver by high-frequency oscillatory ventilation in experimental acute lung injury on organ blood flow in pigs

 

Healthy animal

Lung lavage before PCV

Lung lavage before HFOV

Plateau airway pressure (mbar)

20 ± 2

33* ± 2

34* ± 3

Mean airway pressure (mbar)

9 ± 1

13* ± 2

13* ± 2

Static lung compliance (ml/mbar)

21 ± 1

11* ± 1

10* ± 1

Respiratory rate (minute-1)

16 ± 2

16 ± 2

16 ± 2

tidal volume per kg bodyweight (ml/kg)

12.8 ± 0.8

12.1 ± 0.2

12.3 ± 0.2

expiratory minute ventilation (l/minute)

4.7 ± 0.7

5.0 ± 0.6

4.9 ± 0.6

Heart rate (minute-1)

112 ± 12

127* ± 25

125* ± 18

Mean arterial pressure (mmHg)

80 ± 11

81 ± 6

81 ± 8

Right atrial pressure (mmHg)

13 ± 2

12 ± 3

12 ± 2

Mean pulmonary arterial pressure (mmHg)

26 ± 6

39* ± 6

40* ± 6

Pulmonary artery occlusion pressure (mmHg)

10 ± 3

13 ± 5

14 ± 3

Left ventricular end-diastolic pressure (mmHg)

2 ± 1

3 ± 1

3 ± 1

Intracranial pressure (mmHg)

11 ± 2

13 ± 2

13 ± 1

Cardiac output (l/minute)

3.3 ± 0.3

3.8 ± 0.5

3.7 ± 0.6

Stroke volume (ml)

28 ± 4

29 ± 8

30 ± 6

PaO2 (kPa)

65.9 ± 8.9

10.8* ± 1.7

11.3* ± 1.9

PaCO2 (kPa)

5.5 ± 0.3

5.5 ± 0.4

5.6 ± 0.3

Pulmonary shunt (%)

3 ± 1

38* ± 4

39* ± 9

  1. Measurements taken during volume-controlled ventilation (positive end-expiratory pressure, 5 mbar; FiO2, 1.0). No differences were found between lung-injured animals before transition to either high-frequency oscillatory ventilation (HFOV) or pressure-controlled ventilation (PCV). Data presented as the mean ± standard deviation. Static lung compliance = tidal volume/(plateau airway pressure - positive end-expiratory pressure). *P < 0.01 versus healthy lungs.