Example experiment. Lipopolysaccharide (LPS) infusion resulted in a slight initial decline in the mean arterial pressure (MAP) and a marked decrease in renal blood flow (RBF). Whereas the MAP recovered after 20 minutes, the RBF remained unchanged. Fluid resuscitation with 6 ml HES130/0.4 restored RBF to 20% above baseline values. Cortical (cμPO2) and medullary (mμPO2) microvascular PO2 did not change during LPS infusion. Upon fluid resuscitation cμPO2 markedly decreased.