Skip to main content

Table 3 Baseline and Day 1 protein C activity: effect of drotrecogin alfa (activated) (DrotAA) and proportion of patients that improved or worsened by baseline protein C class

From: Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome

Parameter Treatment group
  Placebo (n = 709) DrotAA (n = 743) P value
Protein C activitya
   Baseline 50% (34, 68) 47% (31, 64) 0.06
   Day 1 47% (30, 72) 52% (36, 72) 0.008
   Day 1 change 0% (-10, 9) 6% (-4, 16) <0.0001
Proportion of patients improved or worsened (% of patients)b
   Baseline protein C ≤ 40% and day 1 protein C >40% 19.4 35.5 <0.0001
   Baseline protein C 40–80% and day 1 protein C decreased ≥ 10% 29.6 17.6 0.0002
   Baseline protein C >80% and day 1 protein C decreased ≥ 10% 30.6 19.8 0.09
  1. aSummary statistics reported as the median (25th percentile, 75th percentile), and P values from Wilcoxon rank-sum tests (P < 0.05 significant). bImproved, baseline protein C ≤ 40% and day 1 protein C >40%; Worsened, baseline protein C 41–80% or >80% and a day 1 decrease in protein C ≥ 10%.