Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome

Table 3 Baseline and Day 1 protein C activity: effect of drotrecogin alfa (activated) (DrotAA) and proportion of patients that improved or worsened by baseline protein C class

Parameter	Treatment group
	Placebo (n = 709)	DrotAA (n = 743)	P value
Protein C activity^a
Baseline	50% (34, 68)	47% (31, 64)	0.06
Day 1	47% (30, 72)	52% (36, 72)	0.008
Day 1 change	0% (-10, 9)	6% (-4, 16)	<0.0001
Proportion of patients improved or worsened (% of patients)^b
Baseline protein C ≤ 40% and day 1 protein C >40%	19.4	35.5	<0.0001
Baseline protein C 40–80% and day 1 protein C decreased ≥ 10%	29.6	17.6	0.0002
Baseline protein C >80% and day 1 protein C decreased ≥ 10%	30.6	19.8	0.09

^aSummary statistics reported as the median (25th percentile, 75th percentile), and P values from Wilcoxon rank-sum tests (P < 0.05 significant). ^bImproved, baseline protein C ≤ 40% and day 1 protein C >40%; Worsened, baseline protein C 41–80% or >80% and a day 1 decrease in protein C ≥ 10%.

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