Figure 1

PROWESS 28-day placebo mortality rates: effect of baseline protein C class. Placebo patient baseline and day 1 protein C levels were assessed and patient outcomes at 28 days determined. Twenty eight-day mortalities, based on baseline protein C and day 1 protein C levels are presented. Mortality of severely deficient patients at baseline increased if protein C levels remained ≤ 40% and decreased if protein C levels increased to >40%. Mortality of deficient (41–80%) and normal (>80%) patients increased if there was a ≥ 10% drop in protein C levels and decreased if there was no drop ≥ 10%. The area/% above the dashed lines in all baseline bar graphs represent patients that died before a day 1 protein C measurement was performed.