Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine

Friesenecker, Barbara E; Tsai, Amy G; Martini, Judith; Ulmer, Hanno; Wenzel, Volker; Hasibeder, Walter R; Intaglietta, Marcos; Dünser, Martin W

doi:10.1186/cc4922

Critical Care

Table 2 Arteriolar diameter, cross-sectional area, blood velocity, and arteriolar flow in norepinephrine and arginine vasopressin animals

From: Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine

Arteriol type	Parameter	Drug	Baseline	Drug infusion	Change (%)	p value
A0	Arteriolar D (μm)	NE^a	127 ± 27	86 ± 16	31 ± 12	0.002^b
		AVP^a	129 ± 7	66 ± 12	49 ± 7
	Arteriolar CSA (μm²)	NE^a	13,083 ± 4,908	5,954 ± 2,150	49 ± 17	0.002^b
		AVP^a	13,100 ± 1,462	3,547 ± 1,173	73 ± 7
	RBC velocity (mm/s)	NE^a	13.5 ± 2.2	10.6 ± 2.3	22 ± 9	0.232
		AVP^a	14.9 ± 0.9	11.2 ± 1.1	25 ± 6
	Arteriolar BF (10^-2 × mm × μm²/s)	NE^a	18.4 ± 8.1	6.6 ± 3.2	62 ± 13	0.004^b
		AVP^a	19.6 ± 2.6	3.9 ± 1.3	80 ± 6
A1	Arteriolar D (μm)	NE^a	47 ± 11	33 ± 8	28 ± 12	0.461
		AVP^a	49 ± 13	66 ± 12	30 ± 12
	Arteriolar CSA (μm²)	NE^a	1,785 ± 878	922 ± 444	47 ± 16	0.461
		AVP^a	2,000 ± 1,080	987 ± 574	50 ± 17
	RBC velocity (mm/s)	NE^a	3.7 ± 0.7	3 ± 0.4	19 ± 9	0.236
		AVP^a	3.9 ± 1	2.9 ± 1.2	27 ± 17
	Arteriolar BF (10^-3 × mm × μm²/s)	NE^a	6.9 ± 4.1	2.8 ± 1.5	57 ± 15	0.096
		AVP^a	8.2 ± 6.2	2.9 ± 2.4	63 ± 14
A2	Arteriolar D (μm)	NE^a	28 ± 12	20 ± 9	29 ± 12	0.156
		AVP^a	25 ± 8	16 ± 5	34 ± 14
	Arteriolar CSA (μm²)	NE^a	748 ± 689	390 ± 332	48 ± 16	0.156
		AVP^a	522 ± 345	226 ± 141	55 ± 18
	RBC velocity (mm/s)	NE^a	3 ± 0.7	2.3 ± 0.4	20 ± 14	0.845
		AVP^a	2.8 ± 0.4	2.2 ± 0.4	21 ± 15
	Arteriolar BF (10^-3 × mm × μm²/s)	NE^a	2.6 ± 3.3	0.9 ± 1.0	59 ± 13	0.212
		AVP^a	1.5 ± 1.2	0.5 ± 0.4	64 ± 19
A3	Arteriolar D (μm)	NE^a	15 ± 6	10 ± 5	34 ± 11	0.110
		AVP^a	16 ± 5	9 ± 3	43 ± 12
	Arteriolar CSA (μm²)	NE^a	193 ± 180	86 ± 96	56 ± 14	0.110
		AVP^a	86 ± 96	74 ± 51	86 ± 13
	RBC velocity (mm/s)	NE^a	2.3 ± 0.4	1.8 ± 0.4	21 ± 16	0.146
		AVP^a	2.4 ± 0.4	1.7 ± 0.6	29 ± 16
	Arteriolar BF (10^-4 × mm × μm²/s)	NE^a	4.7 ± 4.9	1.6 ± 1.6	65 ± 12	0.013
		AVP^a	5.6 ± 4.9	1.3 ± 1.3	76 ± 11
A4	Arteriolar D (μm)	NE^a	9 ± 3	6 ± 1	32 ± 8	0.206
		AVP^a	9 ± 2	7 ± 2	26 ± 12
	Arteriolar CSA (μm²)	NE^a	70 ± 62	28 ± 14	53 ± 10	0.206
		AVP^a	74 ± 41	39 ± 20	44 ± 18
	RBC velocity (mm/s)	NE^a	1.7 ± 0.3	1.3 ± 0.3	21 ± 14	0.464
		AVP^a	1.5 ± 0.3	1.1 ± 0.1	27 ± 19
	Arteriolar BF (10^-4 × mm × μm²/s)	NE^a	1.3 ± 1.4	0.4 ± 0.3	63 ± 10	0.837
		AVP^a	1.2 ± 0.9	0.5 ± 0.3	57 ± 21

Data are given as mean values ± standard deviation. ^aSignificant difference between baseline and drug infusion. ^bSignificant difference of change (%) between arginine vasopressin (AVP) and norepinephrine (NE) animals. BF, blood flow; CSA, cross-sectional area; D, diameter; RBC, red blood cell.

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com