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Table 4 Microbiologic documentation available in visit 2 in modified intention-to-treat patients with nosocomial pneumonia

From: Empiric broad-spectrum antibiotic therapy of nosocomial pneumonia in the intensive care unit: a prospective observational study

  Prior antibiotic therapy Overall Percentage performed Chi-square P value
  No Yes    
Pathogens (%)      0.002
   None 27.5 51.8 52.5   
   Monomicrobial 33.3 29.0 29.9   
   Polymicrobial 39.2 19.2 23.8   
Yield of microbial investigations (%)      
   Tracheal aspirate 87.5 79.5 81.4 81.6  
   Protected specimen brush 96.3 67.9 80.0 32.8  
   Bronchoalveolar lavage 100 71.4 77.5 4.1  
Pathogens identified (all patients)      
   Monomicrobial 17 56 73   0.02
Pseudomonas aeruginosa 1 13 14   
Other Pseudomonas 0 2 2   
Acinetobacter baumannii 0 11 11   
Other Acinetobacter 0 1 1   
Enterobacteriaceae 3 12 15   
Staphylococcus aureus 4 9 13   
Haemophylus influenzae 6 5 11   
Streptococcus pneumoniae 2 2 4   
Streptococcus viridans group 0 0 0   
Other 1 1 2   
   Polymicrobial 20 38 58   <0.001
Mixed, including NFGNB and methicillin-resistant S. aureus 4 23 27   
H. influenzae plus Streptococcus spp. 9 2 11   
Other 7 13 20   
Pathogens identified (Group Va)      
   Monomicrobial 1 7 8   
P. aeruginosa 1 2 3   
Other NFGNB 0 2 2   
Enterobacteriaceae 0 1 1   
Methicillin-resistant S. aureus 0 1 1   
Other 0 1 1   
   Polymicrobial 4 11 15   
Mixed, including NFGNB and methicillin-resistant S. aureus 1 8 9   
Other 3 3 6   
  1. NFGNB, nonfermenting Gram-negative bacilli. Overall, there were 33 Pseudomonas isolates, including 30 Pseudomonas aeruginosa, two Pseudomonas putida, and one Pseudomonas spp., and 22 Acinetobacter isolates, including 20 A. baumannii, one Acinetobacter haemolyticus, and one Acinetobacter calcoaceticus. aGroup V, patients who initially received inadequate antibiotic therapy, which was later modified on the basis of cultures.