Skip to main content

Table 5 Association of Risk, Injury, Failure, Loss, and End-stage Kidney (RIFLE) criteria with mortality

From: RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis

 

Hazard ratio (95% confidence interval)

P

Panel A: association of AKI, defined by meeting any RIFLE criteria, with mortality

  

AKI (reference no AKI)

1.7 (1.28–2.13)

< 0.001

SOFAnonrenal score (per point)

1.1 (1.10–1.15)

< 0.001

Age (per 10 years)

1.1 (1.07–1.18)

< 0.001

Sex (female)

0.9 (0.78–1.07)

0.252

Race (reference white)

 

0.528

   Black

1.1 (0.88–1.45)

0.324

   Other

0.8 (0.41–1.68)

0.608

Medical admission (reference surgical admission)

2.9 (2.44–3.40)

< 0.001

Main reason for admission (reference cardiovascular disease)

 

< 0.001

   Trauma

0.9 (0.66–1.09)

0.196

   Neurological disease

1.3 (1.03–1.52)

0.026

   Pulmonary disease, infection

0.8 (0.65–1.03)

0.087

   Gastrointestinal disease

0.5 (0.21–1.25)

0.140

   Malignancy

0.2 (0.04–0.63)

0.009

   Other

0.4 (0.22–0.62)

< 0.001

Panel B: association of maximum RIFLE class with mortality

  

RIFLEmax (reference no AKI)

 

< 0.001

   Risk

1.0 (0.68–1.56)

0.896

   Injury

1.4 (1.02–1.88)

0.037

   Failure

2.7 (2.03–3.55)

< 0.001

SOFAnonrenal score (per point)

1.1 (1.10–1.14)

< 0.001

Age (per 10 years)

1.1 (1.08–1.20)

< 0.001

Sex (female)

0.9 (0.76–1.06)

0.190

Race (reference white)

 

0.673

   Black

1.1 (0.87–1.45)

0.389

   Other

0.9 (0.44–1.97)

0.844

Medical admission (reference surgical admission)

2.7 (2.27–3.21)

< 0.001

Main reason for admission (reference cardiovascular disease)

 

< 0.001

   Trauma

0.9 (0.69–1.18)

0.463

   Neurological disease

1.3 (1.06–1.60)

0.011

   Pulmonary disease, infection

0.8 (0.66–1.07)

0.154

   Gastrointestinal disease

0.6 (0.24–1.41)

0.230

   Malignancy

0.2 (0.04–0.69)

0.013

   Other

0.3 (0.20–0.60

< 0.001

  1. Covariate-adjusted Cox proportional hazard regression analysis. AKI, acute kidney injury, patients meeting at least one of the RIFLE criteria; RIFLEmax, maximum RIFLE class; SOFAnonrenal, Sequential Organ Failure Assessment score without points for kidney failure, determined on data from the first 24 hours of admission.