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Table 4 Diagnostic and severity criteria for sinusoidal obstruction syndrome

From: Clinical review: Specific aspects of acute renal failure in cancer patients

Diagnostic criteria Hepatomegaly
  Sudden weight gain (+ 2% of body weight)
  Jaundice (total bilirubin >34 μmol/l)
  Right upper quadrant pain
  No other cause:
  Budd-Chiari syndrome
  Sepsis
  Heart failure
  Graft versus host disease
Other symptoms Cytolysis
  Gall bladder wall thickening
  Portal hypertension
  Multiple organ failure
  Thrombocytopenia
Severe sinusoidal obstruction syndrome Multiple organ failure
  Thrombocytopenia
  Cytolysis with ASAT or ALAT >750 IU/l
  Confusion or disorientation
  Maximum total bilirubin or severity of weight gain
  1. LDH, lactate dehydrogenase; TLS, tumour lysis syndrome.