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Table 4 Clinical features of patients according to cause of acute tubular necrosis

From: Patients with ischaemic, mixed and nephrotoxic acute tubular necrosis in the intensive care unit – a homogeneous population?

Clinical feature Cause of acute tubular necrosis
  Ischaemic (n = 265) Mixed (n = 201) Nephrotoxic (n = 58)
Multiorgan failure 122 (46%) 110 (55%) 4 (7%)
Respiratory failure 230 (87%) 193 (96%)‡* 40 (69%)
Shock 220 (83%) 175 (87%) 8 (14%)
Hepatic failure 37 (14%) 16 (8%) 2 (3%)
Coma 106 (40%) 68 (34%) 12 (21%)
Infection 143 (54%) 149 (74%)‡* 31 (53%)
Gastrointestinal bleeding 45 (17%) 24 (12%) 4 (7%)
Oliguria 130 (49%) 116 (58%) 22 (38%)
Hypervolaemia 37 (14%) 40 (20%) 6 (10%)
Acidosis 193 (73%) 163 (81%) 37 (64%)
Admission creatinine (mg/dl) 1.98 ± 0.88 1.81 ± 0.88 1.63 ± 0.85
Peak creatinine (mg/dl) 3.24 ± 1.59 3.41 ± 1.50 2.78 ± 1.03
Discharge creatinine (mg/dl) 2.70 ± 1.47 2.98 ± 1.56* 1.96 ± 0.96
Dialysis 24 (9%) 34 (17%)* 4 (7%)
Mortality 175 (66%) 127 (63%) 22 (38%)
  1. Data are expressed as mean ± standard deviation or as n (%). *P < 0.017 ischaemic versus mixed acute tubular necrosis ATN; P < 0.017 ischaemic versus nephrotoxic ATN; P < 0.017 mixed versus nephrotoxic ATN.