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Table 1 Electrolytic and systemic oxygen-derived variables in both groups

From: Small volume of hypertonic saline as the initial fluid replacement in experimental hypodynamic sepsis

 

Bacterial infusion

Fluid resuscitation

 

Follow up

 

T0

T30

T60

T90

T120

T150

T180

T210

sDO2 (ml/minute)

        

   LR

454 ± 44

214 ± 25a

310 ± 37a

340 ± 48a

246 ± 37a

233 ± 32a

237 ± 40a

222 ± 34a

   HS

415 ± 28

274 ± 19a

350 ± 25a

308 ± 38a

279 ± 24a

292 ± 21a

298 ± 13a

290 ± 23a

sVO2 (ml/minute)

        

   LR

95 ± 11

67 ± 9

64 ± 10

73 ± 10

60 ± 7

68 ± 7

74 ± 7

68 ± 6

   HS

77 ± 11

91 ± 14

61 ± 7

52 ± 7

56 ± 6

60 ± 6

55 ± 6

58 ± 6

sO2ER (%)

        

   LR

20 ± 2.1

31 ± 2.3a

20 ± 3.7

22 ± 3.8

30 ± 5.1

34 ± 4.7a,b

38 ± 6.5a,b

38 ± 5.9a,b

   HS

14 ± 1.9

33 ± 8.3a

15 ± 1.8

14 ± 1.7

19 ± 3.2a

18 ± 2.5

17 ± 2.3

18 ± 2.6

AL (mmol/l)

        

   LR

0.65 ± 0.2

1.30 ± 0.3a

2.28 ± 0.4a

3.57 ± 0.5a

3.48 ± 0.6a

4.08 ± 0.8a

4.60 ± 1.1a

4.90 ± 1.3a

   HS

1.16 ± 0.2

1.76 ± 0.2a

2.67 ± 0.3a

3.55 ± 0.2a

4.02 ± 0.2a

4.11 ± 0.2a

4.10 ± 0.2a

4.20 ± 0.2a

HCO3 (mmol/l)

        

   LR

23.0 ± 0.6

22.6 ± 0.8

21.1 ± 0.7a

21.1 ± 0.7a

20.0 ± 0.5a

18.7 ± 0.6a

17.6 ± 1.0a

17.4 ± 1.2a

   HS

22.5 ± 0.6

21.8 ± 0.7

20.7 ± 0.5a

18.3 ± 0.7

18.6 ± 0.7a

18.3 ± 0.7a

18.1 ± 0.5a

17.6 ± 0.5a

Na (mmol/l)

        

   LR

146.6 ± 0.1

146.7 ± 0.3

147.0 ± 0.5

146.7 ± 0.4b

147.6 ± 0.4b

146.7 ± 0.7b

145.3 ± 0.9b

146.1 ± 0.8b

   HS

145.6 ± 0.7

145.9 ± 0.4

146.4 ± 0.7

157.1 ± 0.7a

155.8 ± 0.7a

156.5 ± 0.6a

155.9 ± 0.7a

155.9 ± 0.7a

Hb (g/dl)

        

   LR

12.9 ± 0.4

13.5 ± 0.5

15.1 ± 0.6a

13.6 ± 0.3

14.1 ± 0.3a

14.4 ± 0.5a

15.3 ± 0.4a

15.6 ± 0.3a

   HS

13.6 ± 0.4

14.2 ± 0.4

15.5 ± 0.5a

13.3 ± 0.6

14.8 ± 0.7

15.5 ± 0.7a

15.9 ± 0.7a

16.5 ± 0.7a

  1. Bacterial infusion: intravenous infusion of 1.2 × 1010 cfu/kg of live Escherichia coli in 30 minutes in both groups. Fluid resuscitation: LR group received lactated Ringer's solution 32 ml/kg over 30 minutes, n = 7; HS group received 7.5% hypertonic saline solution 4 ml/kg over 5 minutes, n = 8. Follow up: 120 minutes without additional interventions. sDO2, systemic oxygen delivery; sVO2, systemic oxygen consumption; sO2ER, systemic oxygen extraction rate; Na, plasmatic sodium; AL, arterial lactate; HCO3, bicarbonate; Hb, hemoglobin. ap < 0.05 versus T0, both groups; bp < 0.05, LR versus HS.