Table 6 Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio of inflammatory markers in diagnosing infection
Variable | Cut-off level | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | Positive likelihood ratio | Negative likelihood ratio |
|---|---|---|---|---|---|---|---|
Procalcitonin | 0.075 ng/ml | 80.2 | 47.8 | 70.8 | 60.4 | 1.5 | 0.41 |
0.1 ng/ml | 71.6 | 62.7 | 75.3 | 58.3 | 1.9 | 0.45 | |
0.25 ng/ml | 48.1 | 89.5 | 87.9 | 52.2 | 4.6 | 0.58 | |
0.5 ng/ml | 37.7 | 95.5 | 93.0 | 49.2 | 8.4 | 0.65 | |
Lipopolysaccharide-binding protein | 20 μg/ml | 78.3 | 64.2 | 77.6 | 65.2 | 2.2 | 0.34 |
40 μg/ml | 37.7 | 91.0 | 86.9 | 48.0 | 4.2 | 0.68 | |
C-reactive protein | 30 mg/l | 80.2 | 62.7 | 77.3 | 66.7 | 2.2 | 0.32 |
50 mg/l | 73.6 | 74.6 | 82.1 | 64.1 | 2.9 | 0.35 | |
100 mg/l | 62.3 | 89.5 | 90.4 | 60.0 | 5.9 | 0.42 | |
IL-6 | 16.3 pg/ml | 79.2 | 64.2 | 77.8 | 66.2 | 2.2 | 0.32 |
25 pg/ml | 70.8 | 77.6 | 83.3 | 62.6 | 3.2 | 0.38 | |
50 pg/ml | 58.5 | 88.0 | 88.6 | 57.3 | 4.9 | 0.47 |