Skip to main content

Table 6 Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio of inflammatory markers in diagnosing infection

From: Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study

Variable Cut-off level Sensitivity (%) Specificity (%) Positive predictive value (%) Negative predictive value (%) Positive likelihood ratio Negative likelihood ratio
Procalcitonin 0.075 ng/ml 80.2 47.8 70.8 60.4 1.5 0.41
  0.1 ng/ml 71.6 62.7 75.3 58.3 1.9 0.45
  0.25 ng/ml 48.1 89.5 87.9 52.2 4.6 0.58
  0.5 ng/ml 37.7 95.5 93.0 49.2 8.4 0.65
Lipopolysaccharide-binding protein 20 μg/ml 78.3 64.2 77.6 65.2 2.2 0.34
  40 μg/ml 37.7 91.0 86.9 48.0 4.2 0.68
C-reactive protein 30 mg/l 80.2 62.7 77.3 66.7 2.2 0.32
  50 mg/l 73.6 74.6 82.1 64.1 2.9 0.35
  100 mg/l 62.3 89.5 90.4 60.0 5.9 0.42
IL-6 16.3 pg/ml 79.2 64.2 77.8 66.2 2.2 0.32
  25 pg/ml 70.8 77.6 83.3 62.6 3.2 0.38
  50 pg/ml 58.5 88.0 88.6 57.3 4.9 0.47