Characteristic | Overall population (n = 106) | Period 1 (2001–2002) (n = 40) | Period 2 (2003–2004) (n = 38) | p d |
---|---|---|---|---|
Age, years | 59.6 ± 14.5 | 58.4 ± 14.5 | 60.5 ± 13.4 | 0.50 |
Male sex, n | 70 (66) | 27 (68) | 27 (71) | 0.81 |
Medical admission, n | 85 (80) | 33 (82) | 30 (79) | 0.78 |
Coexisting conditions, n | ||||
Chronic liver disease | 16 (15) | 6 (15) | 7 (18) | 0.77 |
Immune deficiency | 20 (19) | 8 (20) | 7 (18) | 1.0 |
Chronic renal failure | 9 (8) | 2 (5) | 4 (11) | 0.42 |
Site of infection, n | 0.93 | |||
Respiratory system | 61 (58) | 22 (55) | 22 (58) | |
Intra-abdominal | 19 (18) | 9 (22) | 7 (18) | |
Urinary system | 15 (14) | 4 (10) | 3 (8) | |
Other | 11 (10) | 5 (13) | 6 (16) | |
Microbial type, n | 0.89 | |||
Gram-negative | 22 (21) | 9 (22) | 9 (24) | |
Gram-positive | 32 (30) | 10 (25) | 12 (32) | |
Other/mixed | 15 (14) | 3 (8) | 3 (8) | |
Unknown | 37 (35) | 18 (45) | 14 (36) | |
SAPS II | 58.2 ± 16.3 | 55.2 ± 16.0 | 62.5 ± 16.1 | 0.047 |
SOFA score | 8 (3–21) | 8 (3–20) | 10 (3–21) | 0.012 |
Overt DIC, n | 20 (19) | 7 (18) | 8 (21) | 0.78 |
Need for mechanical ventilation, n | 82 (77) | 30 (75) | 30 (79) | 0.79 |
Length of vasoactive support, days | 6 (1–15) | 6 (1–15) | 6.5 (1–14) | 0.79 |
Time between ICU admission and onset of CRRT, days | 1 (0–7) | 1 (0–7) | 1 (0–7) | 0.86 |
Serum creatininea, μmol/l | 158 (82–480) | 126 (94–380) | 158 (82–480) | 0.47 |
Blood urea nitrogena, mmol/l | 16.2 (5.5–57) | 15.9 (8.8–50.6) | 17.6 (6.2–57) | 0.20 |
Fibrinogena, g/l | 6.2 ± 1.4 | 6.5 ± 1.3 | 6.5 ± 1.4 | 0.86 |
Plateletsa, 103/μl | 114 (8–654) | 107 (8–570) | 92 (11–654) | 0.80 |
Antithrombin activity levela, % | 62.5 ± 19.1 | 53.5 ± 10.4 | 51.9 ± 11.2 | 0.53 |
Femoral angioaccess, n | 66 (62) | 25 (62) | 21 (55) | 0.65 |
APTT ratiob | 2.2 ± 0.7 | 1.9 ± 0.5 | 2.0 ± 0.6 | 0.80 |
Heparin doseb, U/kg | 771 ± 333 | 890 ± 389 | 683 ± 276 | 0.0086 |
Filter clotting rate, % | 22 | 31.8 ± 25.0 | 16.5 ± 15.2 | 0.0018 |
Ultrafiltration rate, ml/kg per hour | 34.1 ± 3.6 | 33.2 ± 3.4 | 34.4 ± 3.7 | 0.14 |
Ratio of delivered to prescribed ultrafiltration, % | 83.1 ± 12.7 | 77.3 ± 12.3 | 86.1 ± 13.2 | 0.0032 |
Length of CRRT, days | 4 (1–9) | 4 (1–8) | 4 (1–8) | 0.85 |
Length of stay in ICU, days | 10 (2–105) | 8 (2–49) | 11 (2–92) | 0.22 |
Expected mortality, % | 59.1 ± 24.1 | 54.0 ± 25.5 | 61.1 ± 23.8 | 0.21 |
ICU mortality, n | 64 (60) | 26 (65) | 22 (58) | 0.64 |
Hospital mortality, n | 66 (62) | 27 (68) | 23 (60) | 0.64 |
O/E ratio | 1.1 [0.9–1.4] | 1.4 [1.1–1.8]c | 1.1 [0.9–1.4] |