Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome

Table 1 Changes in haemodynamic variables, acid-base status, reactive hyperaemia, and vasomotion

Parameters	Group	Baseline	1 hour	P
MAP (mmHg)	AVP/NE*	64 ± 5	81 ± 12	0.047^†
	NE	64 ± 9	66 ± 13
CI (l/min per m²)	AVP/NE	4.1 ± 1.2	3.8 ± 1.1	0.152
	NE	3.5 ± 0.9	3.5 ± 0.8
DO₂I (ml/min/m²)	AVP/NE	571 ± 140	526 ± 130	0.151
	NE	482 ± 111	493 ± 119
VO₂I (mL/min/m²)	AVP/NE	155 ± 39	157 ± 35	0.077
	NE	131 ± 35	137 ± 41
SvO₂ (%)	AVP/NE	72 ± 6	66 ± 13	0.583
	NE	71 ± 9	70 ± 10
NE requirements (μg/kg per min)	AVP/NE*	0.75 ± 0.31	0.51 ± 0.19	0.36
	NE	0.65 ± 0.23	0.76 ± 0.18
Milrinone requirements (μg/kg per min)	AVP/NE	0.44 ± 0.15	0.44 ± 0.16	0.025^†
	NE	0.31 ± 0.2	0.29 ± 0.19
pH	AVP/NE	7.30 ± 0.12	7.30 ± 0.12	0.355
	NE	7.33 ± 0.1	7.32 ± 0.08
Lactate (mmol/l)	AVP/NE	5.9 ± 6.7	6.6 ± 6.3	0.548
	NE	7.6 ± 6.1	7.5 ± 5.6
AUC pre-ischaemic	AVP/NE	21.2 ± 9.4	16.7 ± 7.7	0.089
	NE	15.3 ± 10.2	15.3 ± 9.0
Magnitude of RH (%)	AVP/NE	64 ± 57.2	70 ± 47.5	0.56
	NE	49.4 ± 24.8	48.7 ± 41.7
ODS pre-ischaemic (oscillations/min)	AVP/NE^‡	15.73 ± 5.15	14.38 ± 7.31	0.055^§
	NE	7.49 ± 3.2	10.7 ± 3.81
ODS reperfusion (oscillations/min)	AVP/NE^‡	14.38 ± 4.85	13.78 ± 9.17	0.601^§
	NE	8.99 ± 3.92	10.7 ± 5.7

Data are expressed as mean values ± standard deviation. AUC, area under the curve; AVP, arginine vasopressin; CI, cardiac index; DO₂I, systemic oxygen transport index; MAP, mean arterial pressure; NE, norepinephrine; ODS, oscillation of the Doppler signal; RH, reactive hyperaemia; SvO₂, mixed venous oxygen saturation; VO₂I, systemic oxygen consumption index. *significant difference over time; ^†, significant difference between groups; ^‡, significant difference at baseline between groups; ^§, corrected for baseline differences.

ISSN: 1364-8535