Lung and 'end organ' injury due to mechanical ventilation in animals: comparison between the prone and supine positions

Table 3 Acute lung injury score and apoptotic index in the supine and prone position

	Supine position	Prone position	P value	95% confidence interval
Acute lung injury score	4.63 ± 0.58	2.17 ± 0.19	<0.0001	-3.9 to -1.82
Apoptotic index
Lung dorsal	112 ± 22	45.6 ± 28	0.003	-103.6 to -29.78
Lung ventral	80 ± 28	35 ± 22	0.02	-82.6 to -8.1
P value	0.04	0.046
95% confidence interval	2.37 to 61.09	0.29 to 20.5
Liver	56 ± 21	23 ± 10	0.05	-66.78 to -7.8.1
Kidney	31 ± 14	17 ± 10	NS
Small intestine	22 ± 11	16 ± 11	NS
Diaphragm	10 ± 0.5	0.5 ± 0.4	0.001	-10.6 to -9.01

Acute lung injury score corresponds to the sum of the extent (score 0, 1, 2 and 3 for an extent of 0%, <25%, 25–50% and >50%) and the severity of lung injury (score 0 for no changes, score 1, 2 and 3 more severe changes). The apoptotic index was expressed as the number of apoptotic cells/bodies per 10 high-power fields.

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