Parameter | Group | T0 | T1 | T2 | T3 | p (time effect) | p (treatment effect) | p (interaction) |
---|---|---|---|---|---|---|---|---|
MAP, mmHg | E | 52 ± 7 | 81 ± 5 | 78 ± 4 | 87 ± 13 | 0.225 | 0.232 | 0.224 |
D–N | 56 ± 8 | 79 ± 8 | 80 ± 9 | 80 ± 13 | ||||
RAP, mmHg | E | 11 ± 3 | 13 ± 3 | 12 ± 3 | 10 ± 3 | 0.028 | 0.597 | 0.987 |
D–N | 12 ± 3 | 13 ± 5 | 12 ± 3 | 10 ± 4 | ||||
MPAP, mmHg | E | 23 ± 3 | 29 ± 6 | 29 ± 4 | 27 ± 5 | 0.289 | 0.141 | 0.453 |
D–N | 27 ± 6 | 31 ± 8 | 28 ± 6 | 27 ± 7 | ||||
PCWP, mmHg | E | 14 ± 4 | 15 ± 3 | 15 ± 4 | 14 ± 3 | 0.201 | 0.268 | 0.342 |
D–N | 15 ± 4 | 16 ± 6 | 14 ± 4 | 12 ± 4 | ||||
HR, beats/min | E | 94 ± 18 | 114 ± 24 | 113 ± 12 | 115 ± 14 | 0.991 | 0.023 | 0.699 |
D–N | 102 ± 17 | 108 ± 21 | 109 ± 19 | 109 ± 18 | ||||
SV, ml | E | 68 ± 30 | 92 ± 39 | 87 ± 36 | 81 ± 33 | 0.032 | 0.531 | 0.334 |
D–N | 67 ± 21 | 81 ± 26 | 81 ± 18 | 78 ± 21 | ||||
CO, l/min | E | 6.2 ± 2.4 | 10.1 ± 3.8 | 9.8 ± 4.1 | 9.2 ± 3.4 | 0.115 | 0.039 | 0.454 |
D–N | 6.8 ± 2.2 | 8.6 ± 2.7 | 8.8 ± 2.1 | 8.4 ± 2.6 | ||||
SVR, dyne.s/cm5 | E | 588 ± 188 | 635 ± 335 | 666 ± 400 | 803 ± 438 | 0.006 | 0.743 | 0.141 |
D–N | 621 ± 412 | 722 ± 417 | 672 ± 275 | 746 ± 353 | ||||
PVR, dyne.s/cm5 | E | 142 ± 84 | 122 ± 78 | 145 ± 103 | 143 ± 111 | 0.126 | 0.419 | 0.295 |
D–N | 198 ± 207 | 175 ± 166 | 128 ± 40 | 164 ± 77 | ||||
DO2, ml/min | E | 624 ± 246 | 1,142 ± 442 | 1,160 ± 518 | 1,163 ± 415 | 0.500 | 0.009 | 0.918 |
D–N | 701 ± 220 | 967 ± 306 | 1,021 ± 275 | 968 ± 318 | ||||
VO2, ml/min | E | 180 ± 46 | 275 ± 89 | 286 ± 53 | 250 ± 81 | 0.533 | 0.001 | 0.527 |
D–N | 204 ± 60 | 178 ± 78 | 206 ± 95 | 219 ± 108 | ||||
GMBF, pu | E | 76 (61–107) | 91 (62–136) | 90 (72–133) | 125 (90–160) | 0.084 | 0.048 | 0.913 |
D–N | 106 (93–157) | 137 (99–198) | 133 (114–158) | 165 (124–190) | ||||
GMBF/CO, pu l-1 min-1 | E | 18 (9–20) | 11 (7–17) | 15 (6–17) | 15 (11–18) | 0.128 | 0.015 | 0.686 |
D–N | 15 (10–20) | 17 (11–25) | 15 (10–23) | 18 (11–39) |