Table 3 Patient characteristics for intensive care unit patients with invasive pulmonary aspergillosis and Aspergillus colonisation
Characteristic | Definite invasive aspergillosis (n = 17) | Probable invasive aspergillosis (n = 66) | Invasive aspergillosis (n = 83) | Aspergillus colonisation (n = 89) | P a |
|---|---|---|---|---|---|
Age (years) | 54 (51–63) | 61 (50–69) | 61 (51–69) | 66 (47–72) | 0.186 |
APACHE II score | 28 (21–30) | 28 (20–31) | 28 (19–34) | 24 (20–29) | 0.021 |
Neutropenia | 3 (17.7) | 8 (12.1) | 11 (13.3) | 2 (2.2) | 0.008 |
Hemodynamic instability | 17 (100) | 49 (74.2) | 74 (89.2) | 58 (65.2) | < 0.001 |
Acute renal failure | 10 (58.8) | 23 (34.9) | 33 (39.8) | 23 (25.8) | 0.073 |
Acute respiratory failure | 17 (100) | 63 (95.5) | 80 (96.4) | 77 (86.5) | 0.029 |
Duration of mechanical ventilation prior to first positive culture (days) | 2 (1–8) | 4 (1–9) | 3 (1–8) | 3 (1–7.5) | 0.690 |
Duration of mechanical ventilation (days) | 11 (6–24) | 15 (6–32) | 13 (5–29) | 9 (3–21) | 0.031 |
Length of ICU stay prior to first positive culture (days) | 2 (1–8) | 4 (1–9) | 4 (1–8) | 5 (1–9) | 0.396 |
Length of ICU stay (days) | 11 (7–24) | 15 (7–34) | 14 (7–31) | 13 (6–25) | 0.383 |
Number of cultures positive for Aspergillus spp. | 2 (2–3.5) | 2 (2–3) | 2 (2–3) | 1 (1–2) | < 0.001 |
Number of patients examined with BAL | 12 (70.6) | 49 (74.2) | 61 (73.5) | 29 (32.6) | < 0.001 |
28-days mortality | 15 (88.2) | 44 (66.7) | 59 (49.0) | 26 (23.1) | < 0.001 |
In-hospital mortality | 16 (94.1) | 48 (72.7) | 64 (77.1) | 36 (40.4) | < 0.001 |