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Table 3 Patient characteristics for intensive care unit patients with invasive pulmonary aspergillosis and Aspergillus colonisation

From: Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients

Characteristic Definite invasive aspergillosis (n = 17) Probable invasive aspergillosis (n = 66) Invasive aspergillosis (n = 83) Aspergillus colonisation (n = 89) P a
Age (years) 54 (51–63) 61 (50–69) 61 (51–69) 66 (47–72) 0.186
APACHE II score 28 (21–30) 28 (20–31) 28 (19–34) 24 (20–29) 0.021
Neutropenia 3 (17.7) 8 (12.1) 11 (13.3) 2 (2.2) 0.008
Hemodynamic instability 17 (100) 49 (74.2) 74 (89.2) 58 (65.2) < 0.001
Acute renal failure 10 (58.8) 23 (34.9) 33 (39.8) 23 (25.8) 0.073
Acute respiratory failure 17 (100) 63 (95.5) 80 (96.4) 77 (86.5) 0.029
Duration of mechanical ventilation prior to first positive culture (days) 2 (1–8) 4 (1–9) 3 (1–8) 3 (1–7.5) 0.690
Duration of mechanical ventilation (days) 11 (6–24) 15 (6–32) 13 (5–29) 9 (3–21) 0.031
Length of ICU stay prior to first positive culture (days) 2 (1–8) 4 (1–9) 4 (1–8) 5 (1–9) 0.396
Length of ICU stay (days) 11 (7–24) 15 (7–34) 14 (7–31) 13 (6–25) 0.383
Number of cultures positive for Aspergillus spp. 2 (2–3.5) 2 (2–3) 2 (2–3) 1 (1–2) < 0.001
Number of patients examined with BAL 12 (70.6) 49 (74.2) 61 (73.5) 29 (32.6) < 0.001
28-days mortality 15 (88.2) 44 (66.7) 59 (49.0) 26 (23.1) < 0.001
In-hospital mortality 16 (94.1) 48 (72.7) 64 (77.1) 36 (40.4) < 0.001
  1. Continuous variables are described as median (interquartile range); categorical variables are described as n (%). aP value for invasive aspergillosis (n = 83) versus Aspergillus colonisation (n = 89). No significant differences were observed between patients with proven versus probable invasive aspergillosis. APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; BAL, broncho-alveolar lavage