Figure 1From: Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsisInteraction of antithrombin with endothelium. The affinity of antithrombin (AT) to thrombin and its enzymatic inhibition is increased by binding of AT with the heparan-binding site to cellular heparin sulfate proteoglycans (HSPGs). TAT, thrombin–antithrombin.Back to article page