| | |
NO (ppm)
| | |
|---|
| |
Control 1
|
0.15
|
0.45
|
1.5
|
4.5
|
15
|
45
|
150
|
Control 2
|
P value*
|
|
PaO2/FiO2 (mmHg)
|
128± 18
|
199± 20
|
229± 25
|
232± 28
|
255± 23
|
270± 18
|
283± 24
|
313± 23
|
148± 21
|
0.0001
|
|
QVA/QT (%)
|
37± 2
|
32± 2
|
30± 1
|
29± 1
|
29± 1
|
27± 1
|
29± 1
|
29± 3
|
35± 1
|
0.0001
|
|
SVO2 (%)
|
67± 4
|
72± 2
|
73± 2
|
73± 3
|
74± 3
|
74± 3
|
74± 2
|
73± 3
|
69± 3
|
0.0012
|
|
DO2 (ml/min/m2)
|
416± 38
|
425± 31
|
437± 40
|
455± 41
|
430± 25
|
420± 29
|
417± 35
|
407± 35
|
413± 31
|
0.315
|
|
VO2 (ml/min/m2)
|
126± 13
|
113± 10
|
114± 9
|
124± 16
|
110± 11
|
114± 12
|
109± 9
|
118± 18
|
121± 11
|
0.2372
|
|
PaCO2 (mmHg)
|
44± 3
|
43± 3
|
42± 2
|
41± 3
|
41± 2
|
41± 3
|
41± 2
|
42± 3
|
43± 2
|
0.0114
|
|
PETCO2 (mmHg)
|
30± 2
|
31± 2
|
31± 2
|
30± 2
|
30± 2
|
31± 2
|
30± 2
|
32± 3
|
30± 2
|
0.0829
|
|
VDA/VT (%)
|
30± 4
|
25± 3
|
25± 3
|
24± 4
|
24± 4
|
24± 4
|
25± 4
|
23± 5
|
28± 4
|
0.0008
|
- QVA/QT = venous admixture; SVO2 = mixed venous oxygen saturation; VO2 = oxygen consumption; DO2 = oxygen delivery; PETCO2 = end tidal CO2; VDA/VT = alveolar dead space Values are given as mean ± SEM. *P value for the one-way analysis of variance (dose-response curve).
