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Table 7 Respiratory effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and with septic shock

From: Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

   NO (ppm)   
  Control 1 0.15 0.45 1.5 4.5 15 45 150 Control 2 P value*
PaO2/FiO2 (mmHg) 128± 18 199± 20 229± 25 232± 28 255± 23 270± 18 283± 24 313± 23 148± 21 0.0001
QVA/QT (%) 37± 2 32± 2 30± 1 29± 1 29± 1 27± 1 29± 1 29± 3 35± 1 0.0001
SVO2 (%) 67± 4 72± 2 73± 2 73± 3 74± 3 74± 3 74± 2 73± 3 69± 3 0.0012
DO2 (ml/min/m2) 416± 38 425± 31 437± 40 455± 41 430± 25 420± 29 417± 35 407± 35 413± 31 0.315
VO2 (ml/min/m2) 126± 13 113± 10 114± 9 124± 16 110± 11 114± 12 109± 9 118± 18 121± 11 0.2372
PaCO2 (mmHg) 44± 3 43± 3 42± 2 41± 3 41± 2 41± 3 41± 2 42± 3 43± 2 0.0114
PETCO2 (mmHg) 30± 2 31± 2 31± 2 30± 2 30± 2 31± 2 30± 2 32± 3 30± 2 0.0829
VDA/VT (%) 30± 4 25± 3 25± 3 24± 4 24± 4 24± 4 25± 4 23± 5 28± 4 0.0008
  1. QVA/QT = venous admixture; SVO2 = mixed venous oxygen saturation; VO2 = oxygen consumption; DO2 = oxygen delivery; PETCO2 = end tidal CO2; VDA/VT = alveolar dead space Values are given as mean ± SEM. *P value for the one-way analysis of variance (dose-response curve).