| |
NO (ppm)
| | |
---|
|
Control 1
|
0.15
|
0.45
|
1.5
|
4.5
|
15
|
45
|
150
|
Control 2
|
P value*
|
SPAP (mmHg)
|
48± 5
|
43± 5
|
42± 4
|
40± 4
|
39± 3
|
38± 3
|
36± 3
|
36± 3
|
48± 4
|
0.0001
|
DPAP (mmHg)
|
23± 2
|
19± 2
|
20± 2
|
19± 2
|
18± 2
|
18± 2
|
17± 2
|
17± 2
|
22± 2
|
0.0001
|
MPAP (mmHg)
|
32± 3
|
28± 3
|
28± 3
|
27± 3
|
26± 3
|
26± 2
|
24± 2
|
24± 2
|
31± 3
|
0.0001
|
PVRI (dyn s/cm5m2)
|
513± 60
|
395± 39
|
399± 37
|
383± 45
|
352± 35
|
355± 27
|
351± 25
|
362± 33
|
484± 50
|
0.0001
|
HR (/min)
|
91± 8
|
89± 9
|
91± 8
|
95± 8
|
90± 9
|
89± 9
|
89± 7
|
89± 8
|
93± 7
|
0.5331
|
CI (I/min/m2)
|
3.3± 0.3
|
3.3± 0.3
|
3.2± 0.3
|
3.5± 0.3
|
3.3± 0.3
|
3.2± 0.3
|
3.2± 0.3
|
3.1± 0.3
|
3.2± 0.3
|
0.2356
|
RVSWI (g/m2
|
11± 2
|
10± 2
|
10± 2
|
9± 2
|
9± 2
|
8± 1
|
8± 1
|
7± 1
|
10± 2
|
0.0003
|
RAP (mmHg)
|
10± 2
|
10± 2
|
10± 2
|
9± 2
|
10± 2
|
10± 2
|
9± 2
|
9± 1
|
10± 2
|
0.2142
|
PCWP (mmHg)
|
11± 2
|
11± 1
|
12± 2
|
11± 2
|
11± 2
|
12± 2
|
11± 2
|
10± 2
|
11± 2
|
0.4322
|
MAP (mmHg)
|
74± 5
|
75± 3
|
78± 5
|
77± 3
|
79± 4
|
74± 3
|
73± 4
|
73± 4
|
75± 4
|
0.3197
|
SVRI (dyn s/cm5m2)
|
1709± 236
|
1685± 187
|
1767± 177
|
1695± 184
|
1827± 258
|
1705± 170
|
1731± 219
|
1788± 279
|
1698± 163
|
0.8766
|
- NO = nitric oxide; SPAP = systolic pulmonary arterial pressure; DPAP = diastolic pulmonary arterial pressure; MPAP = mean pulmonary arterial pressure; PVRI = pulmonary vascular resistance index; HR = heart rate; CI = cardiac index; RVSWI = right ventricular stroke work index; RAP = right aterial pressure; PCWP = pulmonary capillary wedge pressure; MAP = mean arterial pressure; SVRI = systemic vascular resistance index. Values are given as mean ± SEM. *P value for the one-way analysis of variance (dose-response curve).