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Table 6 Hemodynamic effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and with septic shock

From: Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

   NO (ppm)   
  Control 1 0.15 0.45 1.5 4.5 15 45 150 Control 2 P value*
SPAP (mmHg) 48± 5 43± 5 42± 4 40± 4 39± 3 38± 3 36± 3 36± 3 48± 4 0.0001
DPAP (mmHg) 23± 2 19± 2 20± 2 19± 2 18± 2 18± 2 17± 2 17± 2 22± 2 0.0001
MPAP (mmHg) 32± 3 28± 3 28± 3 27± 3 26± 3 26± 2 24± 2 24± 2 31± 3 0.0001
PVRI (dyn s/cm5m2) 513± 60 395± 39 399± 37 383± 45 352± 35 355± 27 351± 25 362± 33 484± 50 0.0001
HR (/min) 91± 8 89± 9 91± 8 95± 8 90± 9 89± 9 89± 7 89± 8 93± 7 0.5331
CI (I/min/m2) 3.3± 0.3 3.3± 0.3 3.2± 0.3 3.5± 0.3 3.3± 0.3 3.2± 0.3 3.2± 0.3 3.1± 0.3 3.2± 0.3 0.2356
RVSWI (g/m2 11± 2 10± 2 10± 2 9± 2 9± 2 8± 1 8± 1 7± 1 10± 2 0.0003
RAP (mmHg) 10± 2 10± 2 10± 2 9± 2 10± 2 10± 2 9± 2 9± 1 10± 2 0.2142
PCWP (mmHg) 11± 2 11± 1 12± 2 11± 2 11± 2 12± 2 11± 2 10± 2 11± 2 0.4322
MAP (mmHg) 74± 5 75± 3 78± 5 77± 3 79± 4 74± 3 73± 4 73± 4 75± 4 0.3197
SVRI (dyn s/cm5m2) 1709± 236 1685± 187 1767± 177 1695± 184 1827± 258 1705± 170 1731± 219 1788± 279 1698± 163 0.8766
  1. NO = nitric oxide; SPAP = systolic pulmonary arterial pressure; DPAP = diastolic pulmonary arterial pressure; MPAP = mean pulmonary arterial pressure; PVRI = pulmonary vascular resistance index; HR = heart rate; CI = cardiac index; RVSWI = right ventricular stroke work index; RAP = right aterial pressure; PCWP = pulmonary capillary wedge pressure; MAP = mean arterial pressure; SVRI = systemic vascular resistance index. Values are given as mean ± SEM. *P value for the one-way analysis of variance (dose-response curve).
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