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Table 6 Hemodynamic effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and with septic shock

From: Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

  

NO (ppm)

  
 

Control 1

0.15

0.45

1.5

4.5

15

45

150

Control 2

P value*

SPAP (mmHg)

48± 5

43± 5

42± 4

40± 4

39± 3

38± 3

36± 3

36± 3

48± 4

0.0001

DPAP (mmHg)

23± 2

19± 2

20± 2

19± 2

18± 2

18± 2

17± 2

17± 2

22± 2

0.0001

MPAP (mmHg)

32± 3

28± 3

28± 3

27± 3

26± 3

26± 2

24± 2

24± 2

31± 3

0.0001

PVRI (dyn s/cm5m2)

513± 60

395± 39

399± 37

383± 45

352± 35

355± 27

351± 25

362± 33

484± 50

0.0001

HR (/min)

91± 8

89± 9

91± 8

95± 8

90± 9

89± 9

89± 7

89± 8

93± 7

0.5331

CI (I/min/m2)

3.3± 0.3

3.3± 0.3

3.2± 0.3

3.5± 0.3

3.3± 0.3

3.2± 0.3

3.2± 0.3

3.1± 0.3

3.2± 0.3

0.2356

RVSWI (g/m2

11± 2

10± 2

10± 2

9± 2

9± 2

8± 1

8± 1

7± 1

10± 2

0.0003

RAP (mmHg)

10± 2

10± 2

10± 2

9± 2

10± 2

10± 2

9± 2

9± 1

10± 2

0.2142

PCWP (mmHg)

11± 2

11± 1

12± 2

11± 2

11± 2

12± 2

11± 2

10± 2

11± 2

0.4322

MAP (mmHg)

74± 5

75± 3

78± 5

77± 3

79± 4

74± 3

73± 4

73± 4

75± 4

0.3197

SVRI (dyn s/cm5m2)

1709± 236

1685± 187

1767± 177

1695± 184

1827± 258

1705± 170

1731± 219

1788± 279

1698± 163

0.8766

  1. NO = nitric oxide; SPAP = systolic pulmonary arterial pressure; DPAP = diastolic pulmonary arterial pressure; MPAP = mean pulmonary arterial pressure; PVRI = pulmonary vascular resistance index; HR = heart rate; CI = cardiac index; RVSWI = right ventricular stroke work index; RAP = right aterial pressure; PCWP = pulmonary capillary wedge pressure; MAP = mean arterial pressure; SVRI = systemic vascular resistance index. Values are given as mean ± SEM. *P value for the one-way analysis of variance (dose-response curve).
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Critical Care

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