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Table 5 Respiratory effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and without septic shock

From: Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

   NO (ppm)   
  Control 1 0.15 0.45 1.5 4.5 15 45 150 Control 2 P value*
PaO2/FiO2 (mmHg) 162 ± 23 221 ± 27 220 ± 26 245 ± 27 261 ± 31 275 ± 28 278 ± 30 290 ± 48 177 ± 28 0.0001
QVA/QT (%) 33 ± 3 29 ± 1 30 ± 2 27 ± 2 27 ± 2 27 ± 2 27 ± 2 28 ± 4 33 ± 3 0.0122
SvO2 (%) 65 ± 3 67 ± 3 68 ± 4 66 ± 3 68 ± 3 70 ± 3 70 ± 3 67 ± 3 65 ± 4 0.1753
DO2 (ml/min/m2) 440 ± 45 427 ± 38 446 ± 43 441 ± 48 435 ± 44 452 ± 43 441 ± 44 433 ± 47 422 ± 49 0.9511
VO2 (ml/min/m2) 146 ± 9 141 ± 11 142 ± 10 147 ± 11 138 ± 10 137 ± 6 134 ± 10 144 ± 12 140 ± 12 0.4556
PaCO2 (mmHg) 43 ± 2 41 ± 2 41 ± 2 41 ± 2 41 ± 2 42 ± 2 42 ± 2 43 ± 2 43 ± 2 0.1204
PETCO2 (mmHg) 30 ± 1 29 ± 2 29 ± 2 30 ± 2 30 ± 2 29 ± 2 30 ± 2 30 ± 2 29 ± 2 0.6522
VDA/VT (%) 31 ± 3 29 ± 4 30 ± 4 27 ± 3 27 ± 4 30 ± 3 30 ± 4 29 ± 4 33 ± 3 0.2898
  1. QVA/QT = venous admixture; SvO2 = mixed venous oxygen saturation; VO2 = oxygen consumption; DO2 = oxygen delivery; PETCO2 = end tidal CO2; VDA/VT = alveolar dead space. Values are given as mean ± SEM. *P value for the one-way analysis of variance (dose-response curve).