Table 5 Respiratory effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and without septic shock

From: Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

		NO (ppm)
	Control 1	0.15	0.45	1.5	4.5	15	45	150	Control 2	P value^*
PaO₂/FiO₂ (mmHg)	162 ± 23	221 ± 27	220 ± 26	245 ± 27	261 ± 31	275 ± 28	278 ± 30	290 ± 48	177 ± 28	0.0001
Q_VA/Q_T (%)	33 ± 3	29 ± 1	30 ± 2	27 ± 2	27 ± 2	27 ± 2	27 ± 2	28 ± 4	33 ± 3	0.0122
SvO₂ (%)	65 ± 3	67 ± 3	68 ± 4	66 ± 3	68 ± 3	70 ± 3	70 ± 3	67 ± 3	65 ± 4	0.1753
DO₂ (ml/min/m²)	440 ± 45	427 ± 38	446 ± 43	441 ± 48	435 ± 44	452 ± 43	441 ± 44	433 ± 47	422 ± 49	0.9511
VO₂ (ml/min/m²)	146 ± 9	141 ± 11	142 ± 10	147 ± 11	138 ± 10	137 ± 6	134 ± 10	144 ± 12	140 ± 12	0.4556
PaCO₂ (mmHg)	43 ± 2	41 ± 2	41 ± 2	41 ± 2	41 ± 2	42 ± 2	42 ± 2	43 ± 2	43 ± 2	0.1204
P_ETCO₂ (mmHg)	30 ± 1	29 ± 2	29 ± 2	30 ± 2	30 ± 2	29 ± 2	30 ± 2	30 ± 2	29 ± 2	0.6522
VD_A/V_T (%)	31 ± 3	29 ± 4	30 ± 4	27 ± 3	27 ± 4	30 ± 3	30 ± 4	29 ± 4	33 ± 3	0.2898

Q_VA/Q_T = venous admixture; SvO₂ = mixed venous oxygen saturation; VO₂ = oxygen consumption; DO₂ = oxygen delivery; P_ETCO₂ = end tidal CO₂; VD_A/V_T = alveolar dead space. Values are given as mean ± SEM. ^*P value for the one-way analysis of variance (dose-response curve).

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