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Table 4 Hemodynamic effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and without septic shock

From: Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

  NO (ppm)   
  Control 1 0.15 0.45 1.5 4.5 15 45 150 Control 2 P value*
SPAP (mmHg) 45 ± 5 38 ± 5 37 ± 5 35 ± 4 36 ± 5 34 ± 5 33 ± 4 33 ± 4 43 ± 5 0.0001
DPAP (mmHg) 19 ± 2 17 ± 3 16 ± 2 15 ± 2 16 ± 2 15 ± 2 16 ± 2 15 ± 2 19 ± 2 0.0001
MPAP (mmHg) 29 ± 3 25 ± 3 24 ± 3 24 ± 3 24 ± 3 23 ± 3 23 ± 3 23 ± 3 28 ± 4 0.0001
PVRI (dyn s/cm5m2) 431 ± 105 383 ± 94 345 ± 90 340 ± 82 338 ± 85 321 ± 74 311 ± 83 305 ± 77 438 ± 122 0.0001
HR (beats/min) 94 ± 6 89 ± 6 88 ± 6 88 ± 7 90 ± 6 91 ± 6 88 ± 6 90 ± 6 90 ± 7 0.3188
CI (l/min/m2) 4.3 ± 0.5 4 ± 0.4 4.2 ± 0.5 4.1 ± 0.5 4.1 ± 0.5 4.3 ± 0.5 4.2 ± 0.5 4.2 ± 0.5 4.1 ± 0.5 0.8806
RVSWI (g/m2) 13 ± 1 11 ± 1 11 ± 1 11 ± 1 10 ± 1 10 ± 1 10 ± 1 10 ± 1 13 ± 1 0.0001
RAP (mmHg) 7 ± 2 7 ± 1 8 ± 2 7 ± 1 7 ± 2 7 ± 1 7 ± 2 7 ± 2 7 ± 2 0.8382
PCWP (mmHg) 9 ± 2 8 ± 1 8 ± 2 8 ± 1 9 ± 1 8 ± 1 9 ± 1 9 ± 2 9 ± 1 0.1125
MAP (mmHg) 84 ± 4 76 ± 6 79 ± 3 81 ± 4 86 ± 3 82 ± 3 83 ± 4 83 ± 5 81 ± 5 0.1603
SVRI (dyn s/cm5m2) 1589 ± 215 1432 ± 198 1499 ± 201 1601 ± 224 1720 ± 229 1563 ± 195 1653 ± 247 1651 ± 240 1631 ± 239 0.1339
  1. NO = nitric oxide; SPAP = systolic pulmonary arterial pressure; DPAP = diastolic pulmonary arterial pressure; MPAP = mean pulmonary arterial pressure; PVRI = pulmonary vascular resistance index; HR = heart rate; CI = cardiac index; RVSWI = right ventricular stroke work index; RAP = right atrial pressure; PCWP = pulmonary capillary wedge pressure; MAP = mean arterial pressure; SVRI = systemic vascular resistance index. Values are given as mean ± SEM.*P value for the one-way analysis of variance (dose–response curve).