Table 4 Hemodynamic effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and without septic shock

From: Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

	NO (ppm)
	Control 1	0.15	0.45	1.5	4.5	15	45	150	Control 2	P value^*
SPAP (mmHg)	45 ± 5	38 ± 5	37 ± 5	35 ± 4	36 ± 5	34 ± 5	33 ± 4	33 ± 4	43 ± 5	0.0001
DPAP (mmHg)	19 ± 2	17 ± 3	16 ± 2	15 ± 2	16 ± 2	15 ± 2	16 ± 2	15 ± 2	19 ± 2	0.0001
MPAP (mmHg)	29 ± 3	25 ± 3	24 ± 3	24 ± 3	24 ± 3	23 ± 3	23 ± 3	23 ± 3	28 ± 4	0.0001
PVRI (dyn s/cm⁵m²)	431 ± 105	383 ± 94	345 ± 90	340 ± 82	338 ± 85	321 ± 74	311 ± 83	305 ± 77	438 ± 122	0.0001
HR (beats/min)	94 ± 6	89 ± 6	88 ± 6	88 ± 7	90 ± 6	91 ± 6	88 ± 6	90 ± 6	90 ± 7	0.3188
CI (l/min/m²)	4.3 ± 0.5	4 ± 0.4	4.2 ± 0.5	4.1 ± 0.5	4.1 ± 0.5	4.3 ± 0.5	4.2 ± 0.5	4.2 ± 0.5	4.1 ± 0.5	0.8806
RVSWI (g/m²)	13 ± 1	11 ± 1	11 ± 1	11 ± 1	10 ± 1	10 ± 1	10 ± 1	10 ± 1	13 ± 1	0.0001
RAP (mmHg)	7 ± 2	7 ± 1	8 ± 2	7 ± 1	7 ± 2	7 ± 1	7 ± 2	7 ± 2	7 ± 2	0.8382
PCWP (mmHg)	9 ± 2	8 ± 1	8 ± 2	8 ± 1	9 ± 1	8 ± 1	9 ± 1	9 ± 2	9 ± 1	0.1125
MAP (mmHg)	84 ± 4	76 ± 6	79 ± 3	81 ± 4	86 ± 3	82 ± 3	83 ± 4	83 ± 5	81 ± 5	0.1603
SVRI (dyn s/cm⁵m²)	1589 ± 215	1432 ± 198	1499 ± 201	1601 ± 224	1720 ± 229	1563 ± 195	1653 ± 247	1651 ± 240	1631 ± 239	0.1339

NO = nitric oxide; SPAP = systolic pulmonary arterial pressure; DPAP = diastolic pulmonary arterial pressure; MPAP = mean pulmonary arterial pressure; PVRI = pulmonary vascular resistance index; HR = heart rate; CI = cardiac index; RVSWI = right ventricular stroke work index; RAP = right atrial pressure; PCWP = pulmonary capillary wedge pressure; MAP = mean arterial pressure; SVRI = systemic vascular resistance index. Values are given as mean ± SEM.^*P value for the one-way analysis of variance (dose–response curve).

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