Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

Table 2 Initial hemodynamic and respiratory characteristics of the 16 patients: intermittent positive pressure ventilation, ZEEP and FiO₂= 1.0

	Patients without septic shock
	1	2	3	4	5	6	7	8	Mean ± SEM
PaCO₂ (mmHg)	66	45	41	41	46	49	58	56	50 ± 3
VD_A/V_T (%)	39	26	26	35	18	45	46	33	34 ± 4
PaO₂ (mmHg)	58	107	111	104	81	49	188	64	95 ± 16
Q_VA/Q_T (%)	53	43	34	29	46	71	36	53	46 ± 5
Cqs (ml/cmH₂O)	44	57	52	50	36	25	57	-	46 ± 4
Crs (ml/cmH₂O)	50	56	55	82	29	19	84	58	54 ± 8
MPAP (mmHg)	21	31	20	43	27	28	19	36	28 ± 3
PVRI (dyn s/cm⁵m²)	168	265	443	1329	298	215	246	286	406 ± 135
PCWP (mmHg)	4	11	6	3	7	2	7	10	6 ± 1
CI (l/min/m²)	8.3	6.1	2.6	2.4	5.3	9.7	3.9	7.2	5.7 ± 1
	Patients with septic shock
	9	10	11	12	13	14	15	16	Mean ± SEM
PaCO₂ (mmHg)	55	56	56	57	39	44	33	50	48 ± 3
VD_A/V_T (%)	48	38	33	42	33	23	25	39	35 ± 3
PaO₂ (mmHg)	130	68	59	57	145	106	88	77	88 ± 11
Q_VA/Q_T (%)	50	53	50	51	36	43	41	40	47 ± 2
Cqs (ml/cmH₂O)	43	58	30	26	83	52	39	59	49 ± 6
Crs (ml/cmH₂O)	50	56	48	39	77	57	57	59	56 ± 4
MPAP (mmHg)	24	37	45	31	21	39	27	27	32 ± 3
PVRI (dyn s/cm⁵m²)	399	590	489	377	360	471	321	652	442 ± 40
PWP (mmHg)	4	14	13	5	10	9	14	4	9 ± 1
CI (l/min/m²)	3.9	3.1	5.3	5.4	2.4	5.1	3.3	2.9	4.3 ± 1

VD_A/V_T = alveolar dead space; Q_VA/Q_T = venous admixture; Cqs = quasi-static respiratory compliance; Crs = respiratory compliance (slope of the P-V curve above the lower inflection point); MPAP = mean pulmonary arterial pressure; PVRI = pulmonary vascular resistance index; PCWP = pulmonary capillary wedge pressure; CI = cardiac index.

ISSN: 1364-8535