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Table 2 Individual and mean pharmacokinetic parameters of ceftazidime

From: Continuous infusion of ceftazidime in critically ill patients undergoing continuous venovenous haemodiafiltration: pharmacokinetic evaluation and dose recommendation

Pharmacokinetic parameters Css AUC0–72 CLtot Vd T1/2
Patient 1 35.2 2625.0 59.2 19.0 3.7
Patient 2 34.3 2655.0 60.8 12.4 2.8
Patient 3 28.8 2146.0 72.3 17.7 2.8
Patient 4 32.5 2372.0 64.1 29.4 5.3
Patient 5 36.3 2795.0 57.5 24.1 5.0
Patient 6 33.6 2471.0 62.0 13.7 2.6
Patient 7 34.2 2536.0 61.0 15.8 3.0
Mean 33.5 2514.3 62.4 18.9 3.6
Standard deviation 2.4 211.8 4.8 6.0 1.1
  1. AUC0–72 h, area under the concentration time-curve from time zero to 72 hours (mg/hour per l); CLtot, total clearance of ceftazidime (ml/min); Css, steady-state serum ceftazidime concentration (mg/l); T1/2, elimination half-life (hours); Vd, volume of distribution (l).