Continuous infusion of ceftazidime in critically ill patients undergoing continuous venovenous haemodiafiltration: pharmacokinetic evaluation and dose recommendation

Table 2 Individual and mean pharmacokinetic parameters of ceftazidime

Pharmacokinetic parameters	Css	AUC_0–72	CLtot	Vd	T_1/2
Patient 1	35.2	2625.0	59.2	19.0	3.7
Patient 2	34.3	2655.0	60.8	12.4	2.8
Patient 3	28.8	2146.0	72.3	17.7	2.8
Patient 4	32.5	2372.0	64.1	29.4	5.3
Patient 5	36.3	2795.0	57.5	24.1	5.0
Patient 6	33.6	2471.0	62.0	13.7	2.6
Patient 7	34.2	2536.0	61.0	15.8	3.0
Mean	33.5	2514.3	62.4	18.9	3.6
Standard deviation	2.4	211.8	4.8	6.0	1.1

AUC_{0–72 h}, area under the concentration time-curve from time zero to 72 hours (mg/hour per l); CL_tot, total clearance of ceftazidime (ml/min); Css, steady-state serum ceftazidime concentration (mg/l); T_1/2, elimination half-life (hours); Vd, volume of distribution (l).

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