Time course of acetazolamide-induced changes in serum potassium, sodium and chloride. Effect of 500 mg acetazolamide administration (intravenous) in patients with metabolic alkalosis. Serum chloride exhibited a significant increase, whereas there were no significant changes in serum potassium and sodium concentration. Data are expressed as mean ± standard error values for 15 patients. The P values refer to the time-dependent changes analyzed using one-way analysis of variance.