Time course of acetazolamide-induced changes in pH and three independent variables that determine pH. Effect of 500 mg acetazolamide administration (intravenous) in patients with metabolic alkalosis. Data are expressed as mean ± standard error values for 15 patients. The P values refer to the time-dependent changes analyzed using one-way analysis of variance. pCO2, partial carbon dioxide tension; SIDa, apparent strong ion difference.