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Table 3 Outcomes assessed during follow-up in the Improving Care of ALI Patients (ICAP) study

From: Study protocol: The Improving Care of Acute Lung Injury Patients (ICAP) study

Outcome

Instrument(s)

Time requireda (minutes)

Medical outcomes

   Survival

  

   New medical diagnoses and ICU sequelae

Custom-made survey

4

Impairment and disability

   Hearing

HHIA-S survey [36]

2

   Swallowing

SSQ survey [35]

5

   Nutritional status

Physical examb and custom-made surveyc

5

   Pulmonary function

PFTd

95

Functional status

   Physical function

Physical exame

20

 

ADL survey [33]

2

 

IADL survey [34]

2

 

Six-minute walk distance [54]

20

   Mental function (stress, anxiety and depression)

IES-R survey [55]

5

 

HAD survey [56]

6

   Cognitive function

TICS-M survey [57]

5

   Recovery/return to work

Custom-made survey

5

Quality of life

   Health-related quality of life

EQ-5D survey [32]

2

 

SF-36 survey [53]

12

  1. ADL, Activities of Daily Living; ALI, acute lung injury; EQ-5D, EuroQOL; HAD, Hospital Anxiety and Depression; HHIA-S, Hearing Handicap Inventory for Adults – Screening; IADL, Instrumental Activities of Daily Living; ICU, intensive care unit; IES-R, Impact of Event Scale – Revised; PFT, Pulmonary Function Tests; SF-36, Medical Outcomes Study Short Form 36-Item Health Survey; SSQ, Sidney Swallowing Questionnaire; TICS-M, Telephone Interview of Cognitive Status – Modified.
  2. aDerived from pilot testing. Total time for outcome assessment is about 4 hours per participant, including a total of 50 minutes for transportation of participant between the hospital entrance, research clinic, physical therapy area and PFT laboratory within the hospital buildings. All outcomes are assessed at 3, 6, 12, and 24 months after acute lung injury/acute respiratory distress syndrome diagnosis unless otherwise noted. bIncludes body weight, triceps skin fold thickness, and mid-arm muscle circumference. cIncludes a selection of questions adapted from the Subjective Global Assessment [58]. dIncludes maximal inspiratory pressure (15 minutes to complete), spirometry (20 minutes), diffusion capacity for carbon monoxide (DLCO) with single-breath total lung capacity (TLC) (60 minutes, including wait time at the PFT laboratory). Spirometry, DLCO and TLC are not performed at the 6-month follow-up. eIncludes hand-grip dynamometry and manual muscle strength testing.