Skip to main content

Table 3 Sensitivity and specificity for the prediction of various complications in multiple-trauma patients

From: Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients

Parameter (cutoff value) Predicted risk
  Outcome Infection Sepsis/severe sepsis/septic shock SOFA score ≥12 within 21 days ICU stay >7 days
  AUC (odds ratio, 95% CI) (P < 0.002), chi-square test Sensitivity/specificity (cutoff value) AUC (odds ratio, 95% CI) (P < 0.001) Sensitivity/specificity (cutoff value) AUC (odds ratio, 95% CI) (P < 0.002)
Initial procalcitonin (≥1 ng/ml) 0.732 (-, not increased) 93%/41% (0.62 ng/ml) 0.805 (6.1, 2.5–15.7) 90%/48% (0.53 ng/ml) 0.798 (7.8, 2.8–21.9)
   80%/59% (1.31 ng/ml)   80%/64% (0.97 ng/ml)  
   73%/60% (1.37 ng/ml)   70%/74% (1.36 ng/ml)  
Initial C-reactive protein (>100 mg/l) 0.564 (-, not increased) 87%/37% (105 mg/l) 0.674 (-, not increased) 90%/30% (76 mg/l) 0.639 (-, not increased)
   80%/41% (111 mg/l)   80%/64% (104 mg/l)  
   73%/45% (122 mg/l)   70%/52% (121 mg/l)  
Injury Severity Score (≥20) 0.869 (1.3, 1.1–1.6) 100%/61% (26.0) 0.760 (10.6, 3.3–34.1) 90%/54% (20.0) 0.721 (7.0, 2.2–22.4)
   80%/77% (31.5)   88%/54% (21.5)  
   73%/80% (34.0)   73%/70% (26.0)  
Initial SOFA score (≥12) 0.864 (11.6, 3.3–40.6) 87%/68% (10.5) 0.805 (6.0, 2.0–18.4) 95%/42% (7.5) 0.788 (4.9, 1.7–13.9)
   73%/76% (11.5)   82%/70% (9.5)  
   67%/85% (12.5)   65%/78% (10.5)  
APACHE II score (≥20) 0.783 (13.1, 3.5–48.9) 93%/39% (13.5) 0.685 (-, not increased) 90%/40% (12.5) 0.678 (-, not increased)
   87%/48% (14.5)   82%/46% (13.5)  
   73%/61% (15.5)   57%/66% (15.5)  
  1. APACHE, Acute Physiology and Chronic Health Evaluation; AUC, area under the curve of the receiver operating characteristic; CI, confidence interval; SOFA, Sepsis-related Organ Failure Assessment. AUCs were not significantly different among parameters, when compared with the statistical method of Hanley and McNeil (z < 1.88) for outcome [16].