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Table 3 Sensitivity and specificity for the prediction of various complications in multiple-trauma patients

From: Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients

Parameter (cutoff value)

Predicted risk

 

Outcome

Infection

Sepsis/severe sepsis/septic shock

SOFA score ≥12 within 21 days

ICU stay >7 days

 

AUC (odds ratio, 95% CI) (P < 0.002), chi-square test

Sensitivity/specificity (cutoff value)

AUC (odds ratio, 95% CI) (P < 0.001)

Sensitivity/specificity (cutoff value)

AUC (odds ratio, 95% CI) (P < 0.002)

Initial procalcitonin (≥1 ng/ml)

0.732 (-, not increased)

93%/41% (0.62 ng/ml)

0.805 (6.1, 2.5–15.7)

90%/48% (0.53 ng/ml)

0.798 (7.8, 2.8–21.9)

  

80%/59% (1.31 ng/ml)

 

80%/64% (0.97 ng/ml)

 
  

73%/60% (1.37 ng/ml)

 

70%/74% (1.36 ng/ml)

 

Initial C-reactive protein (>100 mg/l)

0.564 (-, not increased)

87%/37% (105 mg/l)

0.674 (-, not increased)

90%/30% (76 mg/l)

0.639 (-, not increased)

  

80%/41% (111 mg/l)

 

80%/64% (104 mg/l)

 
  

73%/45% (122 mg/l)

 

70%/52% (121 mg/l)

 

Injury Severity Score (≥20)

0.869 (1.3, 1.1–1.6)

100%/61% (26.0)

0.760 (10.6, 3.3–34.1)

90%/54% (20.0)

0.721 (7.0, 2.2–22.4)

  

80%/77% (31.5)

 

88%/54% (21.5)

 
  

73%/80% (34.0)

 

73%/70% (26.0)

 

Initial SOFA score (≥12)

0.864 (11.6, 3.3–40.6)

87%/68% (10.5)

0.805 (6.0, 2.0–18.4)

95%/42% (7.5)

0.788 (4.9, 1.7–13.9)

  

73%/76% (11.5)

 

82%/70% (9.5)

 
  

67%/85% (12.5)

 

65%/78% (10.5)

 

APACHE II score (≥20)

0.783 (13.1, 3.5–48.9)

93%/39% (13.5)

0.685 (-, not increased)

90%/40% (12.5)

0.678 (-, not increased)

  

87%/48% (14.5)

 

82%/46% (13.5)

 
  

73%/61% (15.5)

 

57%/66% (15.5)

 
  1. APACHE, Acute Physiology and Chronic Health Evaluation; AUC, area under the curve of the receiver operating characteristic; CI, confidence interval; SOFA, Sepsis-related Organ Failure Assessment. AUCs were not significantly different among parameters, when compared with the statistical method of Hanley and McNeil (z < 1.88) for outcome [16].