Table 3 Attributes of included trials involving patients with sepsis and organ failure
From: Meta-analysis of hemodynamic optimization: relationship to methodological quality
Study | Population | Intervention | Blinding | Allocation concealment | Co-interventions | Crossover | Mortality end-point | Score | Goals of treatment |
|---|---|---|---|---|---|---|---|---|---|
Tuchschmidt et al. 1992 [16] | Septic shock patients | Fluids, inotropes | No | Inadequate | Not described | >10% | Yes | 9 | CI > 6, SAP > 90 |
Yu et al. 1993 [17] | Sepsis, septic shock, ARDS patients | Fluids, blood, inotropes | No | Inadequate | Not described | >10% | Yes | 8 | DO2 > 600 |
Hayes et al. 1994 [20] | Post-operative patients, sepsis, respiratory failure | Fluids, dobutamine | No | Adequate | Not described | Unclear | Yes | 10 | CI > 4.5, DO2 > 600, VO2 > 170 |
Gattinoni et al. 1995 [22] | High-risk postoperative patients, sepsis, respiratory failure | Fluids and inotropes | No | Adequate | Described, but not adequate | <10% | Yes | 12 | CI > 4.5 or SvO2 > 70% |
Yu et al. 1995 [18] | Sepsis, septic shock, ARDS or hypovolemic shock patients | Fluids, inotropes and vasopressors | No | Inadequate | Not described | >10% | Yes | 8 | DO2 > 600 |
Yu et al. 1998 [19] | SIRS, sepsis, severe sepsis, septic shock, ARDS patients 50–75 years of age | Fluids, afterload reduction, inotropes, amrinone, vasopressors | No | Adequate | Not described | Unclear | Yes | 8 | DO2 > 600 |
Yu et al. 1998 [19] | SIRS, sepsis, severe sepsis, septic shock, ARDS patients >75 years of age | Fluids, afterload reduction, inotropes, amrinone, vasopressors | No | Adequate | Not described | Unclear | Yes | 8 | DO2 > 600 |
Durham et al. 1996 [27] | Critically ill patients | Fluids, inotropes and nitroprusside | No | Adequate | Not described | Unclear | Yes | 9 | DO2 > 600, VO2 > 150 |
Alia et al. 1999 [21] | Septic shock patients or severe sepsis patients | Dobutamine | No | Adequate | Not described | >10% | Yes | 10 | DO2 > 600 |
Rivers et al. 2001 [30] | Severe sepsis and septic shock | Fluids, blood, inotropes and vasopressors | No | Adequate | Not described | >10% | Yes | 11 | SvO2 > 70% |