From: Meta-analysis of hemodynamic optimization: relationship to methodological quality
Study | Population | Intervention | Blinding | Allocation concealment | Co-interventions | Crossover | Mortality end-point | Score | Goals of treatment |
---|---|---|---|---|---|---|---|---|---|
Schultz et al. 1985 [32] | Hip fractured patients | Fluids and inotropes peri-operatively | No | Adequate | Not described | Unclear | Yes | 8 | LVSW/PCWP optimized according to normogram |
Shoemaker et al. 1988 [3] | High-risk surgical patients | Fluids and inotropes begun pre-operatively | No | Inadequate | Not described | Unclear | Yes | 5 | CI > 4.5, DO2 > 600, VO2 > 170 |
Berlauk et al. 1991 [35] | Peripheral vascular surgical patients | Fluids, afterload reduction and inotropes | No | Adequate | Not described | Unclear | Yes | 9 | CI > 2.8, 8 < PCWP < 15, SVR 1,100 |
Fleming et al. 1992 [24] | Trauma patients | Fluids, blood and dobutamine | No | Inadequate | Not described | >10% | Yes | 7 | CI > 4.5, DO2 > 670, VO2 > 166 |
Boyd et al. 1993 [25] | High-risk surgical patients | Fluids and dopexamine | No | Adequate | Described, but not equal | Unclear | Yes | 10 | DO2 > 600 |
Bishop et al. 1995 [26] | Cardiac surgical patients | Fluids and dobutamine | No | Adequate | Not described | >10% | Yes | 10 | CI > 4.5, DO2 > 670, VO2 > 166, PCWP 18 |
Mythen and Webb 1995 [33] | Cardiac surgical patients | Fluids | No | Adequate | Not described | Unclear | Yes | 8 | SV optimized |
Bender et al. 1997 [36] | Elective vascular surgical patients | Fluids, blood, vasodilators, nitroprusside and dopamine | No | Adequate | Not described | Unclear | Yes | 8 | 8 PCWP 14, CI 2.8, SVR 1,100 |
Ziegler et al. 1997 [29] | Elective vascular surgical patients | Fluids, blood, inotropes and vasodilators | No | Adequate | Not described | Unclear | Yes | 9 | SvO2 > 65, PCWP > 12, Hb > 10 |
Sinclair et al. 1997 [34] | Hip fractured patients | Fluids | No | Adequate | Not described | >10% | Yes | 8 | SV optimized to 0.35 < FTc < 0.40 |
Valentine et al. 1998 [37] | Elective aortic surgical patients | Fluids, nitroprusside, nitroglycerine and dopamine | No | Adequate | Not described | Unclear | Yes | 10 | CI > 2.8, 8 PCWP 15, SVR 1,100 |
Ueno et al. 1998 [12] | Elective hepatic surgical patients | Fluids and dobutamine | No | Adequate | Not described | Unclear | No | 7 | CI > 4.5, DO2 > 600, VO2 > 170 |
Boldt et al. 1998 [38] | Pancreatic surgical patients | Dopexamine | Yes | Adequate | Not described | Unclear | No | 8 | MAP 70, CI > 2.5, 12 < PCWP < 14 |
Wilson et al. 1999 [13] | High-risk surgical patients | Dopexamine or noradrenaline | Yes | Adequate | Described, but not equal | Unclear | Yes | 12 | DO2 > 600 |
Lobo et al 2000 [23] | High-risk surgical patients | Fluids and dobutamine | No | Adequate | Described, but not equal | >10% | Yes | 11 | DO2 > 600 |
Velhamos et al. 2000 [14] | Trauma surgical patients | Fluids, blood, inotropes and vasopressors | No | Adequate | Not described | >10% | Yes | 11 | CI > 4.5, DO2 > 600, VO2 > 170, SpO2/FiO2 > 200 |
Polonen et al. 2000 [31] | Cardiac surgical patients | Fluids, blood and inotropes | No | Adequate | Not described | >10% | Yes, but secondary | 7 | SvO2 > 70, lactate levels < 2.0 |
Takala et al. 2000 [15] | High-risk surgical patients | Fluids, blood and dopexamine | Yes | Adequate | Not described | >10% | Yes | 13 | DO2 > 600 |
Bonazzi et al. 2002 [28] | Elective vascular surgical patients | Fluids, inotropes, vasodilators | No | Adequate | Adequate | Unclear | No | 10 | CI > 3.0, 10 < PCWP < 18, SVR < 1,450, DO2 > 600 |
Conway et al. 2002 [39] | Elective gastro-intestinal surgical patients | Fluids | No | Inadequate | Not described | Unclear | Yes | 8 | CO optimized |
Sandham et al. 2003 [40] | High-risk surgical patients | Fluids, blood, inotropes, vasodilators, vasopressors | No | Adequate | Not described | <10% | Yes | 11 | 550 < DO2 < 600, 3.5 < CI < 4.5 |