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Table 5 Accuracy of the separate and combined weaning indices

From: Does taking endurance into account improve the prediction of weaning outcome in mechanically ventilated children?

Index/combination

Threshold valuea

LR+

LR-

LR+/LR- ratio

PPV

NPV

AUC (95% CI)

Single TF indicesb

   RRs (breaths/minute)

< 5

1.69

0.31

5.45

0.86

0.46

0.72 (0.55–0.89)

   RSBp (breaths/minute per ml per kg)

< 2

1.21

0.36

3.36

0.82.

0.43

0.71 (0.56–0.87)

   ROP (cmH 2 O/breaths per minute per ml)

<10

2.13

0.43

4.73

0.89

0.38

0.72 (0.55–0.88)

   Pi max (cmH 2 O)

> 50

1.38

0.62

2.23

0.84

0.30

0.56 (0.35–0.77)

Endurance indices

   PTI (no unit)

< 0.08

1.47

0.53

2.77

0.85

0.33

0.61 (0.43–0.79)

   TTI1 (%)

< 0.2

1.53

0.73

2.10

0.85

0.27

0.55 (0.36–0.74)

   TTI 2 (%)

<0.05

1.71

0.50

3.42

0.86

0.35

0.65 (0.47–0.84)

TF combinationsc

   (0.66 × RRs) + (0.34 × Pimax)

< 1.3

2.49

0.50

4.98

0.90

0.35

0.72 (0.55–0.89)

   (0.5 × RSB) + 0.5 Pimax

< 1.5

1.60

0.57

2.81

0.86

0.32

0.63 (0.45–0.82)

   (0.66 × ROP) + (0.34 × Pi max )

<1.5

2.13

0.43

4.95

0.89

0.38

0.74 (0.60–0.89)

Best TFd and best endurance index combination

(0.6 × ROP) – (0.1 × Pimax) + (0.5 × TTI2)

< 1.3

6.4

0.51

12.55

0.96

0.34

0.76 (0.62–0.90)

  1. All parameters, including RRs, are adjusted to age by a Z-score. All parameters, including P0.1, are adjusted to age, in accordance with the literature. aBest predicting weaning success. bPerformance of each index recommended by the TF. cCombinations of single TF indices; italic text indicates the best performing combination. dBest index from among single TF indices and TF combinations. AUC, area under the receiver operating characteristic curve; CI, confidence interval; LR+, positive likelihood ratio; LR-, negative likelihood ratio; NPV, negative predictive value; Pimax, maximal inspiratory pressure during an occlusion test; PPV, positive predictive value; PTI, pressure-time index; ROP, rapid shallow breathing occlusion pressure; RRs, spontaneous respiratory rate; RSBp, paediatric rapid shallow breathing; TF, Task Force facilitated by the American College of Chest Physician; TTI1, tension-time index obtained from the P0.1 value; TTI2, tension-time index obtained from the Paw value.