Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study

Table 4 Cox proportional hazard model with time to death, right censored at 30 days, as dependent factor

	All patients (n = 3,147)		Propensity matched patients (n = 678)
	Relative hazard (95% CI)	p value	Relative hazard (95% CI)	p value
SAPS II score^a	1.04 (1.04–1.05)	<0.001	1.02 (1.01–1.03)	<0.003
SOFA score^b	1.06 (1.03–1.08)	<0.001	1.05 (1.01–1.10)	0.032
Medical admission	1.78 (1.25–2.21)	<0.001	2.33 (1.63–3.31)	<0.001
Age	1.01 (1.01–1.02)	<0.001	1.02 (1.01–1.03)	0.003
Cirrhosis	2.23 (1.68–2.95)	<0.001	1.91 (1.23–2.98)	0.004
Mean fluid balance	1.30 (1.24–1.37)	0.001	1.30 (1.19–1.42)	<0.001
Hemofiltration	1.25 (1.04–1.50)	0.019	-	-
Albumin administration^b	1.57 (1.11–2.22)	0.012	1.57 (1.19–2.07)	0.001
Propensity score	1.23 (1.12–1.67)	0.003	1.01 (1.01–1.02)	0.020

^aOn admission. ^bOn the day of onset of albumin administration in the albumin group and on the day of admission for other patients. CI, confidence interval; SAPS, simplified acute physiology score; SOFA, sequential organ failure assessment.

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