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Table 2 Therapeutic interventions and changes in physiological parameters during the 8-hour study period

From: Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]

Parameter

Control group

GDT group

p

Intervention

   

   Crystalloid (ml)

960 ± 335

930 ± 221

0.39

   Colloid (ml)

1,204 ± 898

1,907 ± 878

<0.0001

   Blood (ml)

0 (0–485)

125 (0–734)

0.10

   Dopexamine (μg kg-1 min-1)

0.0 (0.0–0.0)

0.75 (0.5–1.0)

<0.0001

Change in variable

   

   DO2I (ml min-1 m-2)

-10 ± 190

+163 ± 249

0.0001

   Stroke volume (ml)

-7.2 ± 28.7

+6.7 ± 26.1

0.01

   CVP (mmHg)

-1.6 ± 6.8

-2.1 ± 5.4

0.69

   Serum lactate (mmol l-1)

-0.6 ± 1.1

-0.3 ± 0.8

0.11

  1. Data are presented as mean ± SD or median (interquartile range). CVP, central venous pressure; DO2I, oxygen delivery index. GDT, goal-directed therapy.