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Table 3 Blood gas analysis and haemodynamic parameters at the end of the 6-hour observational period

From: Early veno-venous haemodiafiltration for sepsis-related multiple organ failure

Parameter

Group 1 (n = 40)

Group 2 (n = 20)

P value

PaO2/FiO2 (mmHg)

139 ± 68

100 ± 68

0.046*

PaCO2 (mmHg)

49 ± 11

53 ± 12

0.18

BE (mmol/l)

-11 ± 4

-13 ± 5

0.10

pH

7.17 ± 0.11

7.11 ± 0.13

0.06

Lactate (mmol/l)

4.3 ± 1.8

5.8 ± 3.2

0.020*

HR (beats/minute)

118 ± 20

113 ± 20

0.48

CI (l/minute per m2)

3.2 ± 1.2

2.9 ± 1

0.39

LVEF (%)

50 ± 16

48 ± 19

0.73

Vasopressor support (choice; n [%])

   Noradrenaline

19 (48%)

9 (45%)

0.97

   Noradrenaline + dobutamine

7 (18%)

4 (20%)

 

   Adrenaline

14 (35%)

7 (35%)

 

Vasopressor support (dosage; μg/kg per minute)

1.1 ± 0.8

2.3 ± 1.4

0.002*

  1. Shown is a comparison of blood gas analysis and haemodynamic parameters at the end of the 6-hour observational period between group 1 (responders) and group 2 (nonresponders). Vasopressor dosage is the cumulative dosage of major catecholamines (noradrenaline [norepinephrine] or adrenaline [epinephrine]), with dobutamine being given at 5 μg/kg per minute. *Statistically significant finding. BE, base excess; CI, cardiac index; FiO2, fractional inspired oxygen; HR, heart rate; LVEF, left ventricular ejection fraction; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension.
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