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Table 1 Hemodynamic variables in rat lungs isolated 12 h after surgical interventions

From: Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture

Hemodynamic variable

Time (minutes)

 

0

30

60

90

120

PPA, cmH2O

     

   Sham

26.0 ± 3.1

24.6 ± 3.1

24.6 ± 2.7

26.0 ± 3.0

26.0 ± 3.0

   CLP

21.9 ± 1.5

23.2 ± 1.3

23.2 ± 1.6

24.6 ± 2.3

 

   CLP+Tezo

24.6 ± 0.9

23.2 ± 0.9

23.2 ± 1.1

21.9 ± 1.2

24.6 ± 1.7

PLA, cmH2O

     

   Sham

14.6 ± 0.6

14.7 ± 0.6

14.9 ± 0.9

15.6 ± 0.9

14.9 ± 0.9

   CLP

13.8 ± 0.4

13.8 ± 0.4

13.8 ± 0.4

13.4 ± 0.8

 

   CLP+Tezo

14.9 ± 0.4

14.9 ± 0.4

14.7 ± 0.4

15.4 ± 0.4

15.2 ± 0.4

RT, cmH2O/ml/min

     

   Sham

0.89 ± 0.1

0.80 ± 0.1

0.83 ± 0.1

0.84 ± 0.1

0.82 ± 0.1

   CLP

0.57 ± 0.1

0.65 ± 0.1

0.67 ± 0.1

0.67 ± 0.1

 

   CLP+Tezo

0.75 ± 0.0

0.67 ± 0.0

0.67 ± 0.1

0.67 ± 0.1

0.71 ± 0.1

ΔPmv, cmH2O

     

   Sham

7.2 ± 0.2

7.2 ± 0.3

7.5 ± 0.3

7.2 ± 0.3

7.5 ± 0.3

   CLP

6.7 ± 0.5

6.5 ± 0.4

6.4 ± 0.4

6.5 ± 0.6

 

   CLP+Tezo

7.6 ± 0.4

7.6 ± 0.4

7.5 ± 0.4

8.0 ± 0.4

7.6 ± 0.5

  1. Data are presented as mean ± SEM. Sham, sham-operated group (n = 5); CLP, cecum ligation and puncture group (n = 7); CLP+Tezo, cecum ligation and puncture + tezosentan group (n = 7). PLA, left atrial pressure; PPA, pulmonary artery pressure; ΔPmv, difference between pulmonary microvascular pressure determined prior to and during a standardized elevation of PLA; RT, total vascular resistance.