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Table 1 Hemodynamic variables in rat lungs isolated 12 h after surgical interventions

From: Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture

Hemodynamic variable Time (minutes)
  0 30 60 90 120
PPA, cmH2O      
   Sham 26.0 ± 3.1 24.6 ± 3.1 24.6 ± 2.7 26.0 ± 3.0 26.0 ± 3.0
   CLP 21.9 ± 1.5 23.2 ± 1.3 23.2 ± 1.6 24.6 ± 2.3  
   CLP+Tezo 24.6 ± 0.9 23.2 ± 0.9 23.2 ± 1.1 21.9 ± 1.2 24.6 ± 1.7
PLA, cmH2O      
   Sham 14.6 ± 0.6 14.7 ± 0.6 14.9 ± 0.9 15.6 ± 0.9 14.9 ± 0.9
   CLP 13.8 ± 0.4 13.8 ± 0.4 13.8 ± 0.4 13.4 ± 0.8  
   CLP+Tezo 14.9 ± 0.4 14.9 ± 0.4 14.7 ± 0.4 15.4 ± 0.4 15.2 ± 0.4
RT, cmH2O/ml/min      
   Sham 0.89 ± 0.1 0.80 ± 0.1 0.83 ± 0.1 0.84 ± 0.1 0.82 ± 0.1
   CLP 0.57 ± 0.1 0.65 ± 0.1 0.67 ± 0.1 0.67 ± 0.1  
   CLP+Tezo 0.75 ± 0.0 0.67 ± 0.0 0.67 ± 0.1 0.67 ± 0.1 0.71 ± 0.1
ΔPmv, cmH2O      
   Sham 7.2 ± 0.2 7.2 ± 0.3 7.5 ± 0.3 7.2 ± 0.3 7.5 ± 0.3
   CLP 6.7 ± 0.5 6.5 ± 0.4 6.4 ± 0.4 6.5 ± 0.6  
   CLP+Tezo 7.6 ± 0.4 7.6 ± 0.4 7.5 ± 0.4 8.0 ± 0.4 7.6 ± 0.5
  1. Data are presented as mean ± SEM. Sham, sham-operated group (n = 5); CLP, cecum ligation and puncture group (n = 7); CLP+Tezo, cecum ligation and puncture + tezosentan group (n = 7). PLA, left atrial pressure; PPA, pulmonary artery pressure; ΔPmv, difference between pulmonary microvascular pressure determined prior to and during a standardized elevation of PLA; RT, total vascular resistance.