Protein kinase Cα in lungs after endothelin-1 (ET-1) administration. (a) Cytosolic and (b) membrane fractions. Data are presented as mean ± SEM. Control, control group (n = 4); ET-1, endothelin-1 group (n = 4); ET-1+Tezo, endothelin-1+tezosentan group (n = 4). †p < 0.05 between control and ET-1 groups; *p > 0.05 between ET-1 and ET-1+Tezo groups.