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Table 4 Fluid infusion requirements

From: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model

  Time (hours)
  -0.5 0 1 2 4 6 10 24 32 48 72
Ringer (ml/kg BW)            
   Placebo 1 ± 0 7 ± 0 21 ± 2 40 ± 4 92 ± 4 134 ± 6 135 ± 6 159 ± 7 186 ± 11 223 ± 13 250 ± 19
   L-SEL-Ab 1 ± 0 7 ± 0 20 ± 2 38 ± 4 90 ± 6 130 ± 9 131 ± 10 157 ± 11 189 ± 16 204 ± 9 219 ± 16
Hematocrit (%)            
   Placebo 42.1 ± 1.3 40.3 ± 1.1 37.8 ± 1.2 35.7 ± 1.4 36.4 ± 1.6 36.6 ± 1.4 40.8 ± 1.5 35.4 ± 2.3 29.1 ± 2.0 27.5 ± 1.6 26.0 ± 2.5
   L-SEL-Ab 40.7 ± 1.6 38.6 ± 1.7 37.8 ± 1.5 34.8 ± 1.3 35.5 ± 1.4 36.5 ± 1.5 40.4 ± 1.8 34.3 ± 1.5 31.4 ± 1.6 29.7 ± 1.2 28.6 ± 2.2
Protein (g/100 ml)            
   Placebo 6.5 ± 0.2 6.1 ± 0.1 5.3 ± 0.2 4.5 ± 0.2 4.2 ± 0.1 4.1 ± 0.1 4.8 ± 0.1 4.6 ± 0.1 4.4 ± 0.2 4.1 ± 0.3 4.5 ± 0.4
   L-SEL-Ab 6.0 ± 0.2 5.7 ± 0.2 5.0 ± 0.1 4.1 ± 0.1 4.0 ± 0.1 4.0 ± 0.2 4.5 ± 0.2 4.1 ± 0.2 4.0 ± 0.2 4.0 ± 0.3 4.4 ± 0.4
  1. Accumulation amount of Ringer's solution over time, hematocrit and total plasma protein concentration in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody (L-SEL-Ab). BW = body weight.