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Table 3 Tissue perfusion parameters in baboons infused with live Escherichia coli and treated with placebo or anti-L-selectin antibody

From: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model

 

Time (hours)

 

-0.5

0

1

2

4

6

10

24

32

48

72

aBE (mEQ/l)

           

   Placebo

2.7 ± 0.5

4.0 ± 0.6

2.4 ± 0.3

0.8 ± 0.4

-0.4 ± 0.5

-0.4 ± 0.5

-3.4 ± 0.9

-6.6 ± 0.9

-2.6 ± 1.3

3.1 ± 2.6

7.9 ± 0.6

   L-SEL-Ab

4.0 ± 0.9

4.3 ± 0.9

3.1 ± 0.9

0.5 ± 1.0

-0.7 ± 1.2

-0.8 ± 1.0

-5.3 ± 1.7

-10.1 ± 2.6

-4.8 ± 2.8

2.2 ± 2.5

7.3 ± 2.1

Lactate (mmol/l)

           

   Placebo

3.4 ± 0.8

3.3 ± 0.8

2.4 ± 0.4

3.5 ± 0.4

5.2 ± 0.4

4.9 ± 0.4

7.3 ± 0.7

12.1 ± 1.0

7.8 ± 0.8

6.7 ± 0.8

5.2 ± 0.6

   L-SEL-Ab

3.9 ± 0.9

3.9 ± 0.9

1.9 ± 0.2

4.3 ± 0.7

6.1 ± 0.9

6.1 ± 0.7

9.2 ± 1.4

14.5 ± 1.9

9.8 ± 1.0

6.7 ± 0.8

6.7 ± 1.1

  1. aBE, arterial base excess; L-SEL-Ab, anti-L-selectin antibody.