From: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model
Time (hours) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
-0.5 | 0 | 1 | 2 | 4 | 6 | 10 | 24 | 32 | 48 | 72 | |
aBE (mEQ/l) | |||||||||||
Placebo | 2.7 ± 0.5 | 4.0 ± 0.6 | 2.4 ± 0.3 | 0.8 ± 0.4 | -0.4 ± 0.5 | -0.4 ± 0.5 | -3.4 ± 0.9 | -6.6 ± 0.9 | -2.6 ± 1.3 | 3.1 ± 2.6 | 7.9 ± 0.6 |
L-SEL-Ab | 4.0 ± 0.9 | 4.3 ± 0.9 | 3.1 ± 0.9 | 0.5 ± 1.0 | -0.7 ± 1.2 | -0.8 ± 1.0 | -5.3 ± 1.7 | -10.1 ± 2.6 | -4.8 ± 2.8 | 2.2 ± 2.5 | 7.3 ± 2.1 |
Lactate (mmol/l) | |||||||||||
Placebo | 3.4 ± 0.8 | 3.3 ± 0.8 | 2.4 ± 0.4 | 3.5 ± 0.4 | 5.2 ± 0.4 | 4.9 ± 0.4 | 7.3 ± 0.7 | 12.1 ± 1.0 | 7.8 ± 0.8 | 6.7 ± 0.8 | 5.2 ± 0.6 |
L-SEL-Ab | 3.9 ± 0.9 | 3.9 ± 0.9 | 1.9 ± 0.2 | 4.3 ± 0.7 | 6.1 ± 0.9 | 6.1 ± 0.7 | 9.2 ± 1.4 | 14.5 ± 1.9 | 9.8 ± 1.0 | 6.7 ± 0.8 | 6.7 ± 1.1 |