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Table 2 Hemodynamic responses in baboons infused with live Escherichia coli and treated with placebo or anti-L-selectin antibody

From: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model

  Time (hours)
  -0.5 0 1 2 4 6 10 24 32 48 72
Heart rate (beats/minute)            
   Placebo 124 ± 3 125 ± 3 156 ± 9 171 ± 7 170 ± 5 160 ± 5 141 ± 7 142 ± 6 138 ± 9 139 ± 5 151 ± 11
   L-SEL-Ab 122 ± 5 121 ± 4 160 ± 9 177 ± 7 165 ± 3 168 ± 6 151 ± 5 142 ± 15 141 ± 14 143 ± 10 158 ± 10
MAP (mmHg)            
   Placebo 113 ± 6 122 ± 3 102 ± 8 72 ± 5 103 ± 5 117 ± 6 95 ± 9 75 ± 11 75 ± 6 65 ± 11 70 ± 6
   L-SEL-Ab 119 ± 4 122 ± 3 104 ± 6 72 ± 5 97 ± 5 111 ± 6 85 ± 10 51 ± 8 51 ± 7 61 ± 12 79 ± 8
CO (l/minute)            
   Placebo 3.1 ± 0.2 3.2 ± 0.2 4.3 ± 0.4 4.6 ± 0.4 4.4 ± 0.4 4.2 ± 0.4 2.5 ± 0.2 3.5 ± 0.4 4.2 ± 0.3 3.6 ± 0.3 3.7 ± 0.2
   L-SEL-Ab 3.1 ± 3.1 3.1 ± 3.1 4.8 ± 4.8 5.5 ± 5.5 4.8 ± 4.8 4.6 ± 4.6 2.5 ± 2.5 3.0 ± 3.0 3.8 ± 3.8 3.6 ± 3.6 3.8 ± 3.8
MPAP (mmHg)            
   Placebo 13 ± 1 14 ± 1 14 ± 1 13 ± 1 14 ± 2 18 ± 2 17 ± 3 17 ± 2 18 ± 3 15 ± 1 16 ± 3
   L-SEL-Ab 13 ± 1 13 ± 1 13 ± 1 14 ± 1 14 ± 1 18 ± 1 16 ± 1 16 ± 2 16 ± 1 16 ± 1 15 ± 3
PWP (mmHg)            
   Placebo 3.5 ± 0.4 3.6 ± 0.5 4.4 ± 0.8 4.5 ± 1.0 4.8 ± 0.9 5.4 ± 0.8 1.4 ± 0.6 1.5 ± 0.5 3.5 ± 0.3 2.0 ± 0.7 1.5 ± 1.0
   L-SEL-Ab 4.6 ± 0.7 4.5 ± 0.6 4.8 ± 0.6 5.5 ± 0.9 4.6 ± 0.8 4.9 ± 0.8 2.9 ± 0.6 2.8 ± 0.4 2.7 ± 0.4 3.6 ± 0.9 3.7 ± 0.3
PVR (dyn s cm-5)            
   Placebo 264 ± 21 258 ± 16 180 ± 11 160 ± 17 180 ± 20 265 ± 41 542 ± 112 399 ± 80 285 ± 58 292 ± 22 301 ± 78
   L-SEL-Ab 220 ± 20 223 ± 18 142 ± 22 124 ± 15 162 ± 21 243 ± 30 441 ± 58 362 ± 50 296 ± 27 267 ± 25 279 ± 70
arterial pO2 (mmHg)            
   Placebo 100.4 ± 6.8 101.5 ± 6.9 97.7 ± 5.2 104.8 ± 4.5 105.0 ± 4.3 100.2 ± 4.3 88.2 ± 2.5 84.7 ± 4.6 76.7 ± 6.4 73.1 ± 7.0 63.4 ± 6.5
   L-SEL-Ab 101.9 ± 5.9 102.2 ± 4.4 105.0 ± 6.3 109.9 ± 4.0 105.9 ± 5.7 103.6 ± 6.0 91.0 ± 5.7 89.1 ± 5.4 82.2 ± 3.5 88.7 ± 7.5 77.6 ± 8.3
arterial pCO2 (mmHg)            
   Placebo 48.8 ± 1.1 46.4 ± 1.0 45.0 ± 1.2 41.1 ± 1.2 34.6 ± 2.3 36.3 ± 0.9 33.2 ± 1.1 33.9 ± 1.9 34.1 ± 2.4 40.5 ± 3.2 45.7 ± 3.3
   L-SEL-Ab 43.7 ± 1.5 43.1 ± 1.5 40.9 ± 0.4 39.1 ± 0.9 35.0 ± 1.7 34.5 ± 0.9 28.9 ± 2.3 31.5 ± 2.3 33.0 ± 3.4 35.3 ± 4.3 40.7 ± 6.1
  1. arterial pCO2, arterial partial carbondioxide pressure; arterial pO2, arterial partial oxygen pressure; CO, cardiac output; L-SEL-Ab, anti-L-selectin antibody; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; PWP, pulmonary arterial wedge pressure; PVR, peripheral vascular resistance.