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Table 2 Hemodynamic responses in baboons infused with live Escherichia coli and treated with placebo or anti-L-selectin antibody

From: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model

 

Time (hours)

 

-0.5

0

1

2

4

6

10

24

32

48

72

Heart rate (beats/minute)

           

   Placebo

124 ± 3

125 ± 3

156 ± 9

171 ± 7

170 ± 5

160 ± 5

141 ± 7

142 ± 6

138 ± 9

139 ± 5

151 ± 11

   L-SEL-Ab

122 ± 5

121 ± 4

160 ± 9

177 ± 7

165 ± 3

168 ± 6

151 ± 5

142 ± 15

141 ± 14

143 ± 10

158 ± 10

MAP (mmHg)

           

   Placebo

113 ± 6

122 ± 3

102 ± 8

72 ± 5

103 ± 5

117 ± 6

95 ± 9

75 ± 11

75 ± 6

65 ± 11

70 ± 6

   L-SEL-Ab

119 ± 4

122 ± 3

104 ± 6

72 ± 5

97 ± 5

111 ± 6

85 ± 10

51 ± 8

51 ± 7

61 ± 12

79 ± 8

CO (l/minute)

           

   Placebo

3.1 ± 0.2

3.2 ± 0.2

4.3 ± 0.4

4.6 ± 0.4

4.4 ± 0.4

4.2 ± 0.4

2.5 ± 0.2

3.5 ± 0.4

4.2 ± 0.3

3.6 ± 0.3

3.7 ± 0.2

   L-SEL-Ab

3.1 ± 3.1

3.1 ± 3.1

4.8 ± 4.8

5.5 ± 5.5

4.8 ± 4.8

4.6 ± 4.6

2.5 ± 2.5

3.0 ± 3.0

3.8 ± 3.8

3.6 ± 3.6

3.8 ± 3.8

MPAP (mmHg)

           

   Placebo

13 ± 1

14 ± 1

14 ± 1

13 ± 1

14 ± 2

18 ± 2

17 ± 3

17 ± 2

18 ± 3

15 ± 1

16 ± 3

   L-SEL-Ab

13 ± 1

13 ± 1

13 ± 1

14 ± 1

14 ± 1

18 ± 1

16 ± 1

16 ± 2

16 ± 1

16 ± 1

15 ± 3

PWP (mmHg)

           

   Placebo

3.5 ± 0.4

3.6 ± 0.5

4.4 ± 0.8

4.5 ± 1.0

4.8 ± 0.9

5.4 ± 0.8

1.4 ± 0.6

1.5 ± 0.5

3.5 ± 0.3

2.0 ± 0.7

1.5 ± 1.0

   L-SEL-Ab

4.6 ± 0.7

4.5 ± 0.6

4.8 ± 0.6

5.5 ± 0.9

4.6 ± 0.8

4.9 ± 0.8

2.9 ± 0.6

2.8 ± 0.4

2.7 ± 0.4

3.6 ± 0.9

3.7 ± 0.3

PVR (dyn s cm-5)

           

   Placebo

264 ± 21

258 ± 16

180 ± 11

160 ± 17

180 ± 20

265 ± 41

542 ± 112

399 ± 80

285 ± 58

292 ± 22

301 ± 78

   L-SEL-Ab

220 ± 20

223 ± 18

142 ± 22

124 ± 15

162 ± 21

243 ± 30

441 ± 58

362 ± 50

296 ± 27

267 ± 25

279 ± 70

arterial pO2 (mmHg)

           

   Placebo

100.4 ± 6.8

101.5 ± 6.9

97.7 ± 5.2

104.8 ± 4.5

105.0 ± 4.3

100.2 ± 4.3

88.2 ± 2.5

84.7 ± 4.6

76.7 ± 6.4

73.1 ± 7.0

63.4 ± 6.5

   L-SEL-Ab

101.9 ± 5.9

102.2 ± 4.4

105.0 ± 6.3

109.9 ± 4.0

105.9 ± 5.7

103.6 ± 6.0

91.0 ± 5.7

89.1 ± 5.4

82.2 ± 3.5

88.7 ± 7.5

77.6 ± 8.3

arterial pCO2 (mmHg)

           

   Placebo

48.8 ± 1.1

46.4 ± 1.0

45.0 ± 1.2

41.1 ± 1.2

34.6 ± 2.3

36.3 ± 0.9

33.2 ± 1.1

33.9 ± 1.9

34.1 ± 2.4

40.5 ± 3.2

45.7 ± 3.3

   L-SEL-Ab

43.7 ± 1.5

43.1 ± 1.5

40.9 ± 0.4

39.1 ± 0.9

35.0 ± 1.7

34.5 ± 0.9

28.9 ± 2.3

31.5 ± 2.3

33.0 ± 3.4

35.3 ± 4.3

40.7 ± 6.1

  1. arterial pCO2, arterial partial carbondioxide pressure; arterial pO2, arterial partial oxygen pressure; CO, cardiac output; L-SEL-Ab, anti-L-selectin antibody; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; PWP, pulmonary arterial wedge pressure; PVR, peripheral vascular resistance.