Table 1 TNF-α and IL-6 in baboons infused with live Escherichia coli and treated with placebo or anti-L-selectin antibody
From: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model
Time (hours) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
-0.5 | 0 | 1 | 2 | 4 | 6 | 10 | 24 | 32 | 48 | 72 | |
TNF-α (pg/ml) | |||||||||||
Placebo | 0 ± 0 | 2 ± 2 | 5,950 ± 1,762 | 6,325 ± 2,026 | 244 ± 71 | 55 ± 18 | 28 ± 15 | 21 ± 7 | 19 ± 7 | 8 ± 5 | 0 ± 0 |
L-SEL-Ab | 6 ± 4 | 1 ± 1 | 9,048 ± 2,227 | 6,648 ± 1,465 | 236 ± 45 | 60 ± 9 | 39 ± 7 | 33 ± 11 | 34 ± 11 | 37 ± 15 | 39 ± 15 |
IL-6 (pg/ml) | |||||||||||
Placebo | 4 ± 3 | 17 ± 8 | 2,059 ± 263 | 6,968 ± 718 | 7,331 ± 963 | 6,082 ± 832 | 5,364 ± 773 | 3,032 ± 900 | 1,921 ± 860 | 2,435 ± 1,635 | 896 ± 73 |
L-SEL-Ab | 13 ± 5 | 6 ± 4 | 2,270 ± 665 | 7,392 ± 802 | 7,490 ± 773 | 7,075 ± 765 | 5,952 ± 500 | 3,547 ± 644 | 2,550 ± 689 | 1,684 ± 761 | 907 ± 77 |