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Table 1 Responses to acute and/or chronic hypoxia in which hypoxia inducible factor-1 is involved

From: Lactate as a marker of energy failure in critically ill patients: hypothesis

Pathway involved Gene controlled References of interest
Glycolysis Aldolase A–C [46,47]
  Enolase 1  
  Glucose transporter 1–3  
  Glyceraldehyde phosphate dehydrogenase  
  Hexokinase 1–2  
  Lactate dehydrogenase A  
  Phosphofructokinase L  
  Pyruvate kinase 1-M  
Erythropoiesis Erythropoietin [48]
Angiogenesis Vascular endothelial growth factor [49]
Vascular tone Endothelin-1 [50-52]
  Nitric oxide synthase 2