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Table 1 Patient characteristics and hemostatic variables before antithrombin substitution

From: Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis

Patient no.

Diagnosis

Organism

Age (years)

APACHE II score

PT (%)

aPTT (sec)

Fibrinogen (mg/dl)

AT (%)

D-dimer (μg/l)

Thrombocyte count

Outcome

1

Pneumonia, SBP

Staphylococcus aureus

56

38

30

73

263

20

2,374

47,000

Died

2

Pneumonia, SBP

Staphylococcus aureus

31

43

18

58

198

23

2,177

24,000

Died

3

SBP

No organism

56

39

37

51

266

39

976

38,000

Survived

4

Pneumonia

Fusobacterium necrophorum

19

35

71

56

490

36

999

55,000

Survived

5

Pneumonia

Streptococcus pneumoniae

50

28

37

77

290

34

6,500

89,000

Survived

6

Pneumonia, AML

Klebsiella sp.

61

30

45

45

80

53

6,500

87,000

Died

7a

Pneumonia, AML

Escherichia coli

62

32

60

50

690

34

1,368

11,000

Survived

8a

Pneumonia

Staphylococcus epidermidis

21

27

52

54

602

36

1,291

31,000

Survived

  1. aPatients who received concomitant low-dose heparin. AT, antithrombin; aPTT, activated partial thromboplastin time; PT, prothrombin time. SBP = spontaneous bacterial peritonitis, AML = acute myelogenous leukemia