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Table 1 Patient characteristics and hemostatic variables before antithrombin substitution

From: Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis

Patient no. Diagnosis Organism Age (years) APACHE II score PT (%) aPTT (sec) Fibrinogen (mg/dl) AT (%) D-dimer (μg/l) Thrombocyte count Outcome
1 Pneumonia, SBP Staphylococcus aureus 56 38 30 73 263 20 2,374 47,000 Died
2 Pneumonia, SBP Staphylococcus aureus 31 43 18 58 198 23 2,177 24,000 Died
3 SBP No organism 56 39 37 51 266 39 976 38,000 Survived
4 Pneumonia Fusobacterium necrophorum 19 35 71 56 490 36 999 55,000 Survived
5 Pneumonia Streptococcus pneumoniae 50 28 37 77 290 34 6,500 89,000 Survived
6 Pneumonia, AML Klebsiella sp. 61 30 45 45 80 53 6,500 87,000 Died
7a Pneumonia, AML Escherichia coli 62 32 60 50 690 34 1,368 11,000 Survived
8a Pneumonia Staphylococcus epidermidis 21 27 52 54 602 36 1,291 31,000 Survived
  1. aPatients who received concomitant low-dose heparin. AT, antithrombin; aPTT, activated partial thromboplastin time; PT, prothrombin time. SBP = spontaneous bacterial peritonitis, AML = acute myelogenous leukemia