Table 1 Baseline characteristics of the patients
Characteristic | rhAPC group (n = 12) | Control group (n = 12) |
|---|---|---|
Age, years | 57 ± 16 | 66 ± 14 |
Male sex (%) | 7 (58) | 7 (58) |
Pre-existing conditions, n | 7 | 16 |
Malignancy | 2 | 7 |
Diabetes | 1 | 3 |
Hypertension | 2 | 2 |
COPD | 1 | 2 |
Myocardial infarction | 0 | 1 |
Pancreatitis | 1 | 1 |
Recent surgery (%) | 3 (25) | 3 (25) |
APACHE II score | 21 ± 6 | 22 ± 6 |
Mechanical ventilation | 12 | 11 |
Shock | 12 | 12 |
Vasopressor use | 11 | 11 |
Renal replacement therapy | 4 | 4 |
Number of dysfunctional organ systems | 4 ± 1 | 3 ± 1 |
SOFA score at inclusion | 10 ± 3 | 9 ± 2 |
Site of infection, n | ||
Lung | 8 | 8 |
Urinary tract | 2 | 0 |
Other | 2 | 4 |
Causes of infection, n | ||
Gram positive | 6 | 4 |
Gram negative | 7 | 5 |
Anaerobes | 0 | 1 |
Fungi | 1 | 2 |