Performance of prognostic models in critically ill cancer patients – a review

Table 1 Overall predictive performance of prognostic models in ICU patients with cancer

					Mortality%
Study	N Solid/metastatic/haematological malignancies	Prognostic score	ROC	Hosmer-Lemeshow goodness-of-fit H or Ĉ test p value	Pred	Obs	SMR
Sculier [20]	261	APACHE II	0.60	0.001 (H)	26.5	33	1.25
	solid 77%	SAPS II	0.67	0.001	26.1		1.26
	metastatic 62%
	haematological 23%
Groeger [12]	805	MPM II	0.63	<0.001 (Ĉ)	22	41	1.86
	230	ICMM	0.81	0.310	ng		1.02
	solid and haematological
Groeger [13]	415	ICMM at 72 h	0.82	0.354 (Ĉ)	ng	ng	1.0
	solid and haematological
Schellongowki [21]	242	APACHE II	0.78	0.058 (Ĉ)	ng	44	1.05
	solid 45%	SAPS II	0.83	0.066	ng
	haematological 55%	ICMM (2)	0.70	0.115	42
Berghmans [22]	247	APACHE II	0.65	0.002 (H)	32	34	1.06
	solid 80.5%	SAPS II	0.72	<0.0001	24		1.42
	metastatic 62%	ICMM (2)	0.79	0.060	28		1.21
	haematological 19.5%
Guiguet [23]	94	SAPS II	0.78	0.750 (H)	ng	60	1
	solid 44.7%
	haematological 55.3%
Staudinger [24]	414	APACHE III	0.75	ng	ng	47
	solid 42%
	haematological 58%
Benoit [25]	124	SAPS II	0.77	0.60 (Ĉ)	ng	54
	haematological 100%	APACHE II	0.71	0.39	ng
Afessa [16]	112	APACHE III	0.70	0.584 (H)	42	46	1.09
	haematological 100%	APACHE II	ng	ng	44		1.03
Soares [26]	542	SAPS II	0.82	<0.001 (H)	47.9	58.7	1.23
	solid 88.8%	APACHE III	0.81	<0.001	42.6		1.38
	haematological 11.2%	ICMM (2)	0.80	<0.001	78.7		0.75
	excluding scheduled	MPM II 24 h	0.79	<0.001	37.7		1.56
	surgical patients	APACHE II	0.75	<0.001	38.2		1.54
		MPM II 0 h	0.73	<0.001	25.0		2.35

Shown are areas under ROC, p value belonging to Hosmer-Lemeshow goodness-of-fit H- or Ĉ- statistics and SMRs for individual mortality prediction models. APACHE, Acute Physiology and Chronic Health Evaluation; ICMM, ICU Cancer Mortality Model; MPM, Mortality Probability Model; ROC, receiver operating curve; SAPS, Simplified Acute Physiology Score; SMR, standardized mortality rate; ng, not given.

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