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Table 1 Differential regulation of endotoxic microcirculatory disorders by coagulatory inhibitors

From: Microcirculatory alterations in ischemia–reperfusion injury and sepsis: effects of activated protein C and thrombin inhibition

Action on microcirculation

LPS

APC

AT

Hirudin

Leukocyte rolling 8/24 hours

↑

↓

↑

↑

Arteriolar leukocyte adhesion

↑

↓

↓

↑

Venular leukocyte adhesion

↑

↓

↓

↑

Capillary perfusion

↓

=

=

↓

  1. Note that hirudin is not antiadhesive and does not protect against endotoxic capillary dysfunction. LPS, lipopolysaccharide; APC, activated protein C; AT, antithrombin.
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Critical Care

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