Deaths | n | (%) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | |
---|---|---|---|---|---|
Age | 1.59 (1.46 – 1.73) | 1.57 (1.44 – 1.73) | |||
<55 | 103 | 469 | (22.0) | per 10 year increase | per 10 year increase |
55 – 60 | 108 | 395 | (27.3) | ||
60 – 64 | 187 | 556 | (33.6) | ||
65 – 69 | 281 | 745 | (37.7) | ||
70 – 74 | 325 | 747 | (43.5) | ||
75 – 79 | 293 | 537 | (54.6) | ||
80+ | 96 | 162 | (59.3) | ||
Sex | |||||
Female | 630 | 1742 | (36.2) | Ref. | Ref |
Male | 763 | 1869 | (40.8) | 1.19 (1.03 – 1.39) | 1.04 (0.88 – 1.22) |
Severe respiratory disease | |||||
No | 827 | 2204 | (37.5) | Ref. | Ref. |
Yes | 487 | 1200 | (40.6) | 1.15 (0.98 – 1.34) | 1.23 (1.03 – 1.46) |
Home ventilation | |||||
No | 1288 | 3337 | (38.6) | Ref. | Ref. |
Yes | 26 | 67 | (38.8) | 1.05 (0.62 – 1.78) | 1.16 (0.65 – 2.07) |
Steroid treatment in previous 6 months | |||||
No | 1204 | 3110 | (38.7) | Ref. | Ref. |
Yes | 110 | 294 | (37.4) | 0.96 (0.74 – 1.24) | 1.00 (0.75 – 1.33) |
Comorbidity: liver disease | |||||
No | 1309 | 3398 | (38.5) | Ref. | Ref. |
Yes | 5 | 6 | (83.3) | 8.22 (0.96 – 70.47) | 3.70 (0.39 – 35.37) |
Comorbidity: cardiovascular disease | |||||
No | 1282 | 3326 | (38.5) | Ref. | Ref. |
Yes | 32 | 78 | (41.0) | 1.03 (0.63 – 1.68) | 0.88 (0.51 – 1.50) |
Comorbidity: chronic renal failure | |||||
No | 1306 | 3393 | (38.5) | Ref. | Ref. |
Yes | 8 | 11 | (72.7) | 3.29 (0.82 – 13.17) | 2.21 (0.50 – 9.77) |
Comorbidity: immunosuppression | |||||
No | 1299 | 3377 | (38.5) | Ref. | Ref. |
Yes | 15 | 27 | (55.6) | 1.92 (0.89 – 4.17) | 1.75 (0.71 – 4.28) |
Comorbidity: metastatic cancer | |||||
No | 1310 | 3398 | (38.6) | Ref. | Ref. |
Yes | 4 | 6 | (66.7) | 3.28 (0.60 – 17.96) | 2.50 (0.43 – 14.66) |
Length of stay before unit admission (days) | 1.02 (1.01 – 1.03) | 1.02 (1.01 – 1.03) | |||
0 | 567 | 1618 | (35.0) | per 1 day increase | per 1 day increase |
1 | 256 | 753 | (34.0) | ||
2 | 111 | 282 | (39.4) | ||
3+ | 449 | 927 | (48.4) | ||
CPR within 24 hours before admission | |||||
No | 1207 | 3291 | (36.7) | Ref. | Ref. |
Yes | 176 | 301 | (58.5) | 2.38 (1.83 – 3.08) | 1.83 (1.37 – 2.45) |
Intubation statusa | |||||
Not intubated | 206 | 684 | (30.1) | Ref. | Ref. |
Definitely/probably intubated | 1187 | 2927 | (40.6) | 1.71 (1.38 – 2.13) | 1.36 (1.07 – 1.73) |
Lowest pHa | 1.31 (1.23 – 1.40) | 1.23 (1.13 – 1.35) | |||
<7.18 | 391 | 758 | (51.6) | per 0.1 decrease | per 0.1 decrease |
7.18–7.25 | 294 | 797 | (36.9) | ||
7.26–7.32 | 259 | 815 | (31.8) | ||
= 7.33 | 297 | 877 | (33.9) | ||
PaCO2 from ABG with lowest pH (kPa)a | 1.09 (0.91 – 1.29) | 1.01 (0.79 – 1.29) | |||
<6.9 | 334 | 784 | (42.6) | per 10 kPa increase | per 10 kPa increase |
6.9–8.6 | 316 | 836 | (37.8) | ||
8.7–10.6 | 270 | 783 | (34.5) | ||
= 10.7 | 320 | 843 | (38.0) | ||
PaO2/FiO2 gradient (kPa)a | 1.17 (1.09 – 1.26) | 1.13 (1.04 – 1.22) | |||
<17.2 | 425 | 871 | (48.8) | per 10 kPa decrease | per 10 kPa decrease |
17.2–22.8 | 300 | 860 | (34.9) | ||
22.9–29.5 | 293 | 856 | (34.2) | ||
= 29.6 | 294 | 852 | (34.5) | ||
Lowest albumin (g/l)a | |||||
<20 | 178 | 303 | (58.8) | 2.73 (2.11 – 3.54) | 1.94 (1.46 – 2.58) |
20–24 | 208 | 477 | (43.6) | 1.49 (1.20 – 1.84) | 1.28 (1.01 – 1.61) |
= 25 or not recorded | 1007 | 2831 | (35.6) | Ref. | Ref. |
Organ system failure: respiratory | |||||
No | 335 | 786 | (42.6) | Ref. | Ref. |
Yes | 1058 | 2825 | (37.5) | 1.09 (0.87 – 1.36) | 0.71 (0.55 – 0.91) |
Organ system failure: cardiovascular | |||||
No | 881 | 2594 | (34.0) | Ref. | Ref. |
Yes | 512 | 1017 | (50.3) | 2.21 (1.87 – 2.62) | 1.48 (1.22 – 1.79) |
Organ system failure: neurological | |||||
No | 1066 | 2978 | (35.8) | Ref. | Ref. |
Yes | 327 | 633 | (51.7) | 1.85 (1.53 – 2.24) | 1.36 (1.10 – 1.68) |
Organ system failure: renal | |||||
No | 1190 | 3346 | (35.6) | Ref. | Ref. |
Yes | 203 | 265 | (76.6) | 5.17 (3.70 – 7.23) | 3.83 (2.67 – 5.47) |
Organ system failure: haematological | |||||
No | 1362 | 3550 | (38.4) | Ref. | Ref. |
Yes | 31 | 61 | (50.8) | 1.65 (0.94 – 2.89) | 1.30 (0.69 – 2.45) |