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Table 5 Multiple logistic regression model of patient factors in relation to ultimate hospital mortality

From: Case mix and outcomes for admissions to UK adult, general critical care units with chronic obstructive pulmonary disease: a secondary analysis of the ICNARC Case Mix Programme Database

  Deaths n (%) Unadjusted OR (95% CI) Adjusted OR (95% CI)
Age     1.59 (1.46 – 1.73) 1.57 (1.44 – 1.73)
   <55 103 469 (22.0) per 10 year increase per 10 year increase
   55 – 60 108 395 (27.3)   
   60 – 64 187 556 (33.6)   
   65 – 69 281 745 (37.7)   
   70 – 74 325 747 (43.5)   
   75 – 79 293 537 (54.6)   
   80+ 96 162 (59.3)   
Sex      
   Female 630 1742 (36.2) Ref. Ref
   Male 763 1869 (40.8) 1.19 (1.03 – 1.39) 1.04 (0.88 – 1.22)
Severe respiratory disease      
   No 827 2204 (37.5) Ref. Ref.
   Yes 487 1200 (40.6) 1.15 (0.98 – 1.34) 1.23 (1.03 – 1.46)
Home ventilation      
   No 1288 3337 (38.6) Ref. Ref.
   Yes 26 67 (38.8) 1.05 (0.62 – 1.78) 1.16 (0.65 – 2.07)
Steroid treatment in previous 6 months      
   No 1204 3110 (38.7) Ref. Ref.
   Yes 110 294 (37.4) 0.96 (0.74 – 1.24) 1.00 (0.75 – 1.33)
Comorbidity: liver disease      
   No 1309 3398 (38.5) Ref. Ref.
   Yes 5 6 (83.3) 8.22 (0.96 – 70.47) 3.70 (0.39 – 35.37)
Comorbidity: cardiovascular disease      
   No 1282 3326 (38.5) Ref. Ref.
   Yes 32 78 (41.0) 1.03 (0.63 – 1.68) 0.88 (0.51 – 1.50)
Comorbidity: chronic renal failure      
   No 1306 3393 (38.5) Ref. Ref.
   Yes 8 11 (72.7) 3.29 (0.82 – 13.17) 2.21 (0.50 – 9.77)
Comorbidity: immunosuppression      
   No 1299 3377 (38.5) Ref. Ref.
   Yes 15 27 (55.6) 1.92 (0.89 – 4.17) 1.75 (0.71 – 4.28)
Comorbidity: metastatic cancer      
   No 1310 3398 (38.6) Ref. Ref.
   Yes 4 6 (66.7) 3.28 (0.60 – 17.96) 2.50 (0.43 – 14.66)
Length of stay before unit admission (days)     1.02 (1.01 – 1.03) 1.02 (1.01 – 1.03)
   0 567 1618 (35.0) per 1 day increase per 1 day increase
   1 256 753 (34.0)   
   2 111 282 (39.4)   
   3+ 449 927 (48.4)   
CPR within 24 hours before admission      
   No 1207 3291 (36.7) Ref. Ref.
   Yes 176 301 (58.5) 2.38 (1.83 – 3.08) 1.83 (1.37 – 2.45)
Intubation statusa      
   Not intubated 206 684 (30.1) Ref. Ref.
   Definitely/probably intubated 1187 2927 (40.6) 1.71 (1.38 – 2.13) 1.36 (1.07 – 1.73)
Lowest pHa     1.31 (1.23 – 1.40) 1.23 (1.13 – 1.35)
   <7.18 391 758 (51.6) per 0.1 decrease per 0.1 decrease
   7.18–7.25 294 797 (36.9)   
   7.26–7.32 259 815 (31.8)   
   = 7.33 297 877 (33.9)   
PaCO2 from ABG with lowest pH (kPa)a     1.09 (0.91 – 1.29) 1.01 (0.79 – 1.29)
   <6.9 334 784 (42.6) per 10 kPa increase per 10 kPa increase
   6.9–8.6 316 836 (37.8)   
   8.7–10.6 270 783 (34.5)   
   = 10.7 320 843 (38.0)   
PaO2/FiO2 gradient (kPa)a     1.17 (1.09 – 1.26) 1.13 (1.04 – 1.22)
   <17.2 425 871 (48.8) per 10 kPa decrease per 10 kPa decrease
   17.2–22.8 300 860 (34.9)   
   22.9–29.5 293 856 (34.2)   
   = 29.6 294 852 (34.5)   
Lowest albumin (g/l)a      
   <20 178 303 (58.8) 2.73 (2.11 – 3.54) 1.94 (1.46 – 2.58)
   20–24 208 477 (43.6) 1.49 (1.20 – 1.84) 1.28 (1.01 – 1.61)
   = 25 or not recorded 1007 2831 (35.6) Ref. Ref.
Organ system failure: respiratory      
   No 335 786 (42.6) Ref. Ref.
   Yes 1058 2825 (37.5) 1.09 (0.87 – 1.36) 0.71 (0.55 – 0.91)
Organ system failure: cardiovascular      
   No 881 2594 (34.0) Ref. Ref.
   Yes 512 1017 (50.3) 2.21 (1.87 – 2.62) 1.48 (1.22 – 1.79)
Organ system failure: neurological      
   No 1066 2978 (35.8) Ref. Ref.
   Yes 327 633 (51.7) 1.85 (1.53 – 2.24) 1.36 (1.10 – 1.68)
Organ system failure: renal      
   No 1190 3346 (35.6) Ref. Ref.
   Yes 203 265 (76.6) 5.17 (3.70 – 7.23) 3.83 (2.67 – 5.47)
Organ system failure: haematological      
   No 1362 3550 (38.4) Ref. Ref.
   Yes 31 61 (50.8) 1.65 (0.94 – 2.89) 1.30 (0.69 – 2.45)
  1. Ultimate hospital mortality excludes admissions who were readmissions to the intesnive care unit within the same hospital stay, admissions whose ultimate hospital discharge status was missing, and admissions for whom any of the entered risk factors were missing. aDuring first 24 hours following unit admission. ABG, arterial blood gas; CI, confidence interval; CPR, cardiopulmonary resuscitation; FiO2, fractional inspired oxygen; OR, odds ratio; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension.